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NCT ID: NCT00731692 Completed - Clinical trials for Primary Progressive Multiple Sclerosis

FTY720 in Patients With Primary Progressive Multiple Sclerosis

INFORMS
Start date: July 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate whether FTY720 is effective in delaying MS disability progression compared to placebo in patients with PPMS.

NCT ID: NCT00731549 Completed - Schizophrenia Clinical Trials

Intramuscular Depot Formulation of Aripiprazole as Maintenance Treatment in Patients With Schizophrenia

ASPIRE
Start date: December 2008
Phase: Phase 3
Study type: Interventional

To evaluate the overall effectiveness of aripiprazole intramuscular (IM) depot as maintenance treatment in patients with schizophrenia.

NCT ID: NCT00731224 Completed - Alzheimer's Disease Clinical Trials

Compliance and Tolerability of Rivastigmine Transdermal Patch 10 cm² in Patients With Probable Alzheimer's Disease.

CARE
Start date: July 2008
Phase: Phase 4
Study type: Interventional

This study will evaluate compliance, tolerability, safety, efficacy and caregiver burden of rivastigmine patch 10 cm² treatment in people with Alzheimer's disease (MMSE 10-26) initiating therapy for the first time with a cholinesterase inhibitor, and in patients who were unresponsive to previous cholinesterase inhibitor treatment in a community setting.

NCT ID: NCT00730977 Completed - Healthy Clinical Trials

A Pilot Study to Investigate Administration of Mannitol Via a Novel Dry Powder Inhaler Device

Start date: August 2008
Phase: Phase 1/Phase 2
Study type: Interventional

A novel dry powder inhaler device will be used to administer mannitol to healthy subjects and subjects with bronchiectasis in single doses higher than previously given.The main objective is to assess tolerability of these doses using the new device.

NCT ID: NCT00730288 Completed - Dengue Clinical Trials

Study of ChimeriVax™ Dengue Tetravalent Vaccine in Adult Subjects

Start date: August 2006
Phase: Phase 2
Study type: Interventional

To evaluate effect of previous flavivirus exposure on the safety and immunogenicity of the ChimeriVax™ dengue tetravalent vaccine Primary Objectives: - To describe the safety of one injection of ChimeriVax™ dengue tetravalent vaccine. - To describe the immune response against dengue before and after one injection of ChimeriVax™ dengue tetravalent vaccine

NCT ID: NCT00725036 Completed - Diabetes Clinical Trials

Long Term Safety Trial to Compare Insulin Treatment With Preprandial Inhaled Human Insulin to s.c. Insulin Aspart Both Combined With NPH in Subjects With Type 1 Diabetes

Start date: September 2, 2002
Phase: Phase 3
Study type: Interventional

This trial is conducted in Oceania. The aim of this trial is to compare the safety of using pulmonary inhaled human insulin to s.c. insulin aspart both combined with NPH insulin in subjects with type 1 diabetes.

NCT ID: NCT00724503 Completed - Colorectal Cancer Clinical Trials

FOLFOX Plus SIR-SPHERES MICROSPHERES Versus FOLFOX Alone in Patients With Liver Mets From Primary Colorectal Cancer

SIRFLOX
Start date: August 2006
Phase: N/A
Study type: Interventional

This study is a randomized multi-center trial that will assess the effect of adding Selective Internal Radiation Therapy (SIRT), using SIR-Spheres microspheres®, to a standard chemotherapy regimen of FOLFOX as first line therapy in patients with non-resectable liver metastases from primary colorectal adenocarcinoma. Treatment with the biologic agent bevacizumab, if part of the standard of care at participating institutions, is allowed within this study at the discretion of the treating Investigator.

NCT ID: NCT00723957 Completed - Clinical trials for Advanced/Metastatic Non-Small Cell Lung Cancer

A Randomized Phase 2 Study of Ixabepilone Plus Carboplatin and Paclitaxel Plus Carboplatin in Advanced Nonsmall-Cell Lung Cancer

Start date: December 2008
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether progression-free survival with ixabepilone is superior to that achieved with paclitaxel plus carboplatin in participants with advanced nonsmall-cell lung cancer and beta III (βIII)-tubulin-positive tumors.

NCT ID: NCT00722046 Completed - Alzheimer's Disease Clinical Trials

Multiple IV Dose Study Of PF-04360365 In Patients With Mild To Moderate Alzheimer's Disease

Start date: December 5, 2008
Phase: Phase 2
Study type: Interventional

Purpose of the study is to determine whether multiple dose administration of PF-04360365 is safe and well tolerated in patient with mild to moderate Alzheimer's disease.

NCT ID: NCT00721123 Completed - Clinical trials for Rheumatoid Arthritis

A Long-term Extension Study of Tocilizumab (Myeloma Receptor Antibody [MRA]) in Patients With Rheumatoid Arthritis

Start date: August 2005
Phase: Phase 3
Study type: Interventional

This open-label, international multi-center extension study WA18695 was designed to assess the long term safety of tocilizumab in patients who had moderate to severe active rheumatoid arthritis (RA). Patients enrolled in the WA18695 study had previously received treatment in the 24-week, placebo-controlled, Phase III Study WA17822. Eligible patients were assigned to treatment with 8 mg/kg tocilizumab every 4 weeks for a maximum of 5 years.