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NCT ID: NCT05521542 Recruiting - Clinical trials for Coronary Artery Disease

ADVANCEd NanoTherapies Dual Active Pharmacological Ingredient (Dual-API) Drug-Coated Balloon to Treat De-Novo Lesions in Patients With Symptomatic Stable Coronary Artery Disease

ADVANCE-DCB
Start date: January 30, 2023
Phase: N/A
Study type: Interventional

This prospective, single-arm, multi-center, safety and feasibility first-in-human study will evaluate the safety and feasibility of the SirPlux™ Duo Dual-API Coated PTCA Balloon Catheter to treat de-novo lesions between ≥2.25 and ≤4.0 mm in patients with stable symptomatic coronary artery disease.

NCT ID: NCT05521412 Active, not recruiting - Prostate Cancer Clinical Trials

EValuation of radIOLigand Treatment in mEn With Metastatic Castration-resistant Prostate Cancer With [161Tb]Tb-PSMA-I&T

VIOLET
Start date: September 29, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

This clinical trial will evaluate the safety and efficacy of [161Tb]Tb -PSMA-I&T in men with metastatic castration-resistant prostate cancer (mCRPC).

NCT ID: NCT05521022 Recruiting - Clinical trials for Amyloidosis; Systemic

Study of AT-02 in Healthy Volunteers and Subjects With Systemic Amyloidosis

AT02-001
Start date: September 1, 2022
Phase: Phase 1
Study type: Interventional

This is a multicenter, international, three-part, Phase 1 study designed to evaluate the safety, tolerability, and PK of rising single doses of AT-02 in healthy volunteers and in subjects with systemic amyloidosis and to assess the safety, tolerability, and PK of multiple doses of AT-02 in subjects with systemic amyloidosis.

NCT ID: NCT05519839 Completed - COVID-19 Clinical Trials

A Study to Evaluate the Safety and Immunogenicity of COVID-19 and Influenza Combination Vaccine

COVID-19
Start date: December 30, 2022
Phase: Phase 2
Study type: Interventional

This is a randomized, observer-blinded, Phase 2 study evaluating the safety and immunogenicity of a severe acute respiratory syndrome coronavirus 2 (SARSCoV2) recombinant spike (rS) (SARS-CoV-2 rS) nanoparticle and quadrivalent hemagglutinin (HA) nanoparticle influenza vaccine (qNIV) combination vaccine with Matrix-M™ adjuvant; this combination vaccine.

NCT ID: NCT05519449 Recruiting - Prostate Cancer Clinical Trials

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

Start date: September 15, 2022
Phase: Phase 1
Study type: Interventional

This study is a first-in-human, Phase 1, open-label, multicenter study to assess the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and the preliminary efficacy of JANX007 administered as a single agent in adults with metastatic castration-resistant prostate cancer (mCRPC).

NCT ID: NCT05519085 Recruiting - Clinical trials for Relapsed or Refractory Multiple Myeloma

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

SUCCESSOR-1
Start date: September 20, 2022
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.

NCT ID: NCT05518578 Recruiting - Epilepsy Clinical Trials

Safety and Tolerability Study of SPN-817 in Adult Patients With Treatment Resistant Epilepsy

Start date: February 7, 2023
Phase: Phase 2
Study type: Interventional

This study will evaluate the safety and tolerability of SPN-817 in adults with treatment resistant seizures

NCT ID: NCT05518149 Recruiting - Clinical trials for Depressive Disorder, Major

A Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD)

VENTURA-LT
Start date: September 22, 2022
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the long-term safety and tolerability of aticaprant administered as adjunctive therapy to a current antidepressant (selective serotonin reuptake inhibitor [SSRI] or serotonin and norepinephrine reuptake inhibitor [SNRI]) in all participants with major depressive disorder (MDD).

NCT ID: NCT05518123 Recruiting - Migraine Clinical Trials

Efficacy and Tolerability of Rimegepant for the Prevention of Migraine in Adults With History of Inadequate Response to Oral Preventive Medications

Start date: November 7, 2022
Phase: Phase 4
Study type: Interventional

This study is being conducted to evaluate the efficacy and tolerability of rimegepant for migraine prophylaxis in adults with a history of inadequate response to oral preventive medications

NCT ID: NCT05517564 Enrolling by invitation - Clinical trials for Non-alcoholic Steatohepatitis

First-in-Human Study of GM-60106 in Healthy Adults and Otherwise Healthy Adults With an Increased Body Mass Index and Markers of Non-Alcoholic Fatty Liver Disease

Start date: August 1, 2022
Phase: Phase 1
Study type: Interventional

This is a Phase 1a/1b, randomised, double-blind, placebo-controlled single- and multiple-ascending dose study to evaluate the safety, tolerability, PK, and PD of GM-60106 in healthy adult male and female participants and otherwise healthy adults who have an increased BMI and markers of NAFLD.