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NCT ID: NCT00195676 Completed - Psoriasis Clinical Trials

Efficacy and Safety of Adalimumab in Subjects With Moderate to Severe Chronic Plaque Psoriasis

Start date: May 2004
Phase: Phase 3
Study type: Interventional

The two objectives of this study were to evaluate long-term efficacy and safety of adalimumab treatment in participants who had moderate to severe chronic plaque psoriasis and to evaluate the effectiveness of adalimumab retreatment in participants who had therapeutic response to adalimumab and were then withdrawn from adalimumab treatment.

NCT ID: NCT00195663 Completed - Clinical trials for Early Rheumatoid Arthritis

Efficacy and Safety of Adalimumab and Methotrexate (MTX) Versus MTX Monotherapy in Subjects With Early Rheumatoid Arthritis

PREMIER
Start date: December 2000
Phase: Phase 3
Study type: Interventional

The purpose of the study is to assess the safety and efficacy of adalimumab in combination with methotrexate in patients with recent onset rheumatoid arthritis (RA), and to assess the long-term safety and maintenance of efficacy after treatment with adalimumab for up to 10 years.

NCT ID: NCT00195507 Completed - Psoriasis Clinical Trials

Study Evaluating Etanercept in the Treatment of Subjects With Psoriasis

Start date: December 2004
Phase: Phase 4
Study type: Interventional

This study will provide a direct comparison of 'continuous therapy' and 'intermittent therapy' with withdrawal and retreatment upon return of psoriasis.

NCT ID: NCT00195442 Completed - Hemophilia A Clinical Trials

Study Evaluating Refacto For Pharmacovigilance

Start date: July 1999
Phase: N/A
Study type: Observational

The purpose of this study is to investigate the effectiveness and safety of treatment with ReFacto under conditions of routine therapy. Furthermore a continuous benefit/risk assessment will be done.

NCT ID: NCT00195221 Completed - Hemophilia B Clinical Trials

Study to Describe the Allergic Reactions to Factor IX in Patients With Hemophilia B

Start date: February 2005
Phase: Phase 4
Study type: Observational

Retrospective, multicenter study in patients with hemophilia B. This study will be placed at 20 to 50 hemophilia treatment centers in North America and the EU, and is designed to estimate the frequency of Class II and III allergic reactions in association with the administration of any FIX concentrate. Following informed consent and eligibility, historical patient information including demographics, allergy history, hemophilia history, frequency and severity of allergic reaction(s), number of exposure days with products causing allergic reactions, exposure days to blood products including FIX concentrates, treatment for allergic reaction(s), outcome of event(s), any other adverse event(s) occuring within 48 hours of onset of allergic reaction(s), rechallenge and outcome, switch to another FIX product (if applicable) and outcome, current status of patient, and results of any special studies (eg, skin or RAST testing, alloantibody analyses, ect) will be collected.

NCT ID: NCT00193674 Completed - Clinical trials for Recurrent Miscarriage

Habitual Abortion Study: Oral Dydrogesterone Treatment During Pregnancy in Women With Recurrent Miscarriage

Start date: September 2003
Phase: Phase 3
Study type: Interventional

The purpose of this clinical study is to demonstrate the shift from inflammatory cytokines to non-inflammatory cytokines in women suffering from habitual abortion treated with dydrogesterone (Duphaston).

NCT ID: NCT00191893 Completed - Osteoporosis Clinical Trials

Bone Effects of Teriparatide Following Alendronate

Start date: September 2003
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the effect of 24 months of treatment with once daily teriparatide injection (recombinant human PTH [1-34]) 20 micrograms on bone histomorphometry and architecture. Patients will include postmenopausal, osteoporotic women who have been treated long term (at least 36 months) with alendronate, as well as postmenopausal, osteoporotic women who have never been treated for osteoporosis.

NCT ID: NCT00190671 Completed - Breast Cancer Clinical Trials

A Study of Pemetrexed and Cyclophosphamide Given Every 21 Days in Advanced Breast Cancer Patients

Start date: June 2005
Phase: Phase 1/Phase 2
Study type: Interventional

This is the phase 2 portion of a phase 1/2 trial, testing the use of pemetrexed and cyclophosphamide in combination for the treatment of advanced breast cancer. A single arm Phase 1 dose finding (establish maximum tolerated dose) study precedes the randomized phase 2 portion.

NCT ID: NCT00189839 Completed - Clinical trials for Kidney Transplantation

A Study to Evaluate the Safety and Efficacy of FK506E (MR4) in Patients Undergoing Primary Kidney Transplantation

Start date: August 2004
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate and to compare the efficacy and safety of a triple modified release tacrolimus FK506E (MR4) / MMF / steroid regimen with a triple standard tacrolimus FK506 / MMF / steroid regimen in patients undergoing kidney transplantation. It shall be demonstrated that FK506E (MR4) is non-inferior to FK506 with regards to the primary endpoint.

NCT ID: NCT00189735 Completed - Clinical trials for Kidney Transplantation

A Study to Evaluate FK778 in Kidney Transplant Patients

Start date: September 2003
Phase: Phase 2
Study type: Interventional

A dose finding study to evaluate the safety and effectiveness of FK778 in kidney transplant patients