Clinical Trials Logo

Filter by:
NCT ID: NCT00307437 Completed - Psoriasis Clinical Trials

A Study of the Safety and Efficacy of Ustekinumab (CNTO 1275) in Patients With Moderate to Severe Psoriasis

Start date: May 2005
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to evaluate the efficacy and safety of ustekinumab (CNTO 1275) in the treatment of patients with moderate to severe plaque psoriasis.

NCT ID: NCT00307073 Completed - Bradycardia Clinical Trials

Adapta Pacing System Clinical Study

Start date: May 2005
Phase: N/A
Study type: Interventional

Pacemakers are implantable devices that pace (electrically stimulate) the heart. Some pacemakers have special programs to treat irregular atrial rhythms(top chambers of the heart beat too fast or too slow). Advances in pacemaker technology in recent years include features that automatically adapt to patient conditions without intervention from the clinician. Adapta (Model #ADDR01) is a new pacemaker that is designed to provide further automaticity advances by including the managed ventricular pacing (MVP) feature designed to promote intrinsic conduction (natural flow of electricity in the heart) by reducing unnecessary ventricular (lower chamber of the heart) pacing (electrical impulses). Adapta also contains a feature called TherapyGuide that is designed to allow the user to select certain conditions for each subject and receive a list of suggested pacemaker parameter value changes based on those conditions. The purpose of this study is to evaluate the overall system safety and clinical performance of the Adapta pacing system.

NCT ID: NCT00306215 Completed - Crohn's Disease Clinical Trials

A Study to Evaluate the Efficacy and Safety of CCX282-B in Subjects With Moderate to Severe Crohn's Disease

Start date: March 2006
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether CCX282-B is effective in treating patients with moderate to severe Crohn's Disease.

NCT ID: NCT00306202 Completed - Leukemia Clinical Trials

Study of Dasatinib in Children and Adolescents With Relapsed or Refractory Leukemia

Start date: March 31, 2006
Phase: Phase 1
Study type: Interventional

The purpose of this clinical research study was to establish a recommended phase 2 once daily (QD) dose of dasatinib and to assess the efficacy of the investigational drug for relapsed or refractory (resistant to previous treatment) leukemia in children and adolescents. The side effects that this oral investigational drug may have in children, and the levels of the drug in the blood, will be studied at different doses.

NCT ID: NCT00303056 Completed - Joint Disease Clinical Trials

Efficacy and Safety Study of Intra-articular Multiple Doses of Icatibant in Patients With Painful Knee Osteoarthritis

Start date: February 2006
Phase: Phase 2
Study type: Interventional

The primary objective is to compare the overall treatment effect on pain relief between icatibant and placebo. The secondary objectives are to assess the efficacy of icatibant in term of onset, extent and duration of pain relief relative to triamcinolone, to evaluate the safety of icatibant, to evaluate overall conditions of daily life after treatment with icatibant, to assess systemic exposure of icatibant following intra-articular injection.

NCT ID: NCT00300846 Completed - Schizophrenia Clinical Trials

A Study of Adjunctive Treatment of Aripiprazole in Schizophrenic Patients

Start date: December 2005
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the effect on patient weight of adjunctive therapy of aripiprazole with clozapine versus clozapine monotherapy, in schizophrenic patients who are not optimally controlled on clozapine.

NCT ID: NCT00300508 Completed - Breast Neoplasms Clinical Trials

3 Years of Anastrozole vs. no Treatment as Extended Adjuvant Therapy for Postmenopausal Women With Breast Cancer

Start date: January 1996
Phase: Phase 3
Study type: Interventional

The study assesses the effect of a further 3 years adjuvant treatment with anastrozole vs. an untreated control group after initial 5 years of adjuvant hormone-therapy.

NCT ID: NCT00300274 Completed - Graft Rejection Clinical Trials

Efficacy and Safety of Everolimus in Recipients of Heart Transplants to Prevent Acute and Chronic Rejection

Start date: January 2006
Phase: Phase 3
Study type: Interventional

This trial was to examine the impact of everolimus and reduced dose of cyclosporine on efficacy and safety compared to mycophenolate mofetil and a standard dose of cyclosporine in heart transplant recipients.

NCT ID: NCT00299546 Completed - Clinical trials for Arthritis, Rheumatoid

A Study of the Safety and Efficacy of Golimumab (CNTO 148) in Subjects With Active Rheumatoid Arthritis Previously Treated With Biologic Anti-TNFa Agent(s)

Start date: February 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of golimumab (CNTO 148) in subjects who have active rheumatoid arthritis and have been treated previously with at least 1 dose of a biologic anti-TNFa agent (etanercept, adalimumab or infliximab).

NCT ID: NCT00297960 Completed - Clinical trials for Healthy Male Volunteers

Influence of Treatment With Olanzapine or Ziprasidone on Transcapillary Glucose Transport in Human Skeletal Muscle

Start date: April 2005
Phase: Phase 4
Study type: Interventional

Healthy volunteers will undergo euglycaemic hyperinsulinaemic clamp and microdialysis before and after administration of 10mg olanzapine or 80mg ziprasidone during 10 days.