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NCT ID: NCT00420849 Completed - Multiple Myeloma Clinical Trials

A Multicentre, Single-arm, Open-label Safety Study of Lenalidomide Plus Dexamethasone in Previously Treated Subjects With Multiple Myeloma

Start date: November 2006
Phase: Phase 3
Study type: Interventional

This is a multi-centre, single-arm treatment study combining lenalidomide plus high dose dexamethasone. Subjects who qualify for participation will receive lenalidomide plus high dose dexamethasone in 4 week cycles. Subjects will be seen every 2 weeks for the first 3 cycles of therapy and then every 4 weeks after the third cycle until disease progression is documented, study drug is discontinued for any reason or lenalidomide becomes commercially available for this indication. Assessments of safety and quality of life are performed during the study.

NCT ID: NCT00420212 Completed - Clinical trials for Relapsing-Remitting Multiple Sclerosis

Efficacy and Safety of Oral BG00012 in Relapsing-Remitting Multiple Sclerosis

DEFINE
Start date: January 2007
Phase: Phase 3
Study type: Interventional

To determine if treatment with BG00012 can decrease the number of MS relapses during a certain time period. To determine if, over time, BG00012 treatment can decrease the number of certain types of brain lesions commonly seen in MS patients and slow down the time it takes for the disease to get worse. The purpose of this study is also to determine the safety of BG00012 and how well it is tolerated. Another goal is to see what effect BG00012 may have on tests and evaluations used to assess MS.

NCT ID: NCT00420082 Completed - Clinical trials for Seasonal Allergic Rhinitis

A Randomized, Double-Blind, 4-way Crossover Study to Evaluate the Efficacy of Bilastine in the Vienna Challenge Chamber

Start date: October 2006
Phase: Phase 2
Study type: Interventional

This is a randomized, double blind, active and placebo controlled, 4 way crossover study in patients with seasonal allergic rhinitis. Patients will receive a single dose of bilastine 20 mg, Cetirizine 10 mg, Fexofenadine 120 mg, and placebo in the Vienna Challenge Chamber.

NCT ID: NCT00419718 Completed - Diabetes Clinical Trials

Effect of Exercise on the Absorption of Inhaled Human Insulin in Subjects With Type 1 Diabetes

Start date: October 2005
Phase: Phase 1
Study type: Interventional

The trial is conducted in Europe. This clinical pharmacology trial investigates the effect of exercise on the pharmacokinetics and pharmacodynamics of inhaled insulin in subjects with type 1 diabetes.

NCT ID: NCT00418457 Completed - Breast Neoplasms Clinical Trials

Regional Anesthesia and Breast Cancer Recurrence

Start date: January 2007
Phase: Phase 3
Study type: Interventional

In this multi-center trial, Stage 1-3 patients having mastectomies or isolated lumpectomy with axillary node dissection will be randomly assigned to thoracic epidural or paravertebral anesthesia/analgesia, or to general anesthesia and morphine analgesia. Participants will be followed for up to 10 years to determine the rate of cancer recurrence or metastasis.

NCT ID: NCT00417820 Completed - Psoriasis Clinical Trials

Study of the Safety, Tolerability and Efficacy of BCT194 in Healthy Volunteers and Patients With Psoriasis.

Start date: November 2006
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the local tolerability of a single topical administration of BCT194 in healthy volunteers and, potentially, to evaluate the safety, tolerability, and efficacy of a multiple topical administrations in patients with psoriasis.

NCT ID: NCT00416936 Completed - Personnel, Hospital Clinical Trials

Bacterial Contamination of Anaesthetists' Hands by Personal Mobile Phones Used in the Operating Theatre

Start date: January 2007
Phase: N/A
Study type: Observational

The use of mobile phones in the operating room (OR) has become widespread, because of the lack of reports on serious problems. Since mobile phones are used in close body contact and since, as for most non-medical electronic equipment, there are no cleaning guidelines that meet hospital standards, the hygiene risk involved in using mobile phones in the OR has not yet been determined.

NCT ID: NCT00416520 Completed - Clinical trials for Chronic Kidney Disease

A Phase III, Multicentre, Double-Blind, Placebo-Controlled Withdrawal Study in Patients With Hyperphosphatemia

Start date: June 2007
Phase: Phase 3
Study type: Interventional

This is a phase III multi-centre study in three periods: the first period is a phosphate binder washout for 4 weeks, the second period is an open-label, randomised, parallel group, flexible dose, the third period is a placebo-controlled withdrawal comparing MCI-196 with placebo for 4 weeks.

NCT ID: NCT00414583 Completed - Clinical trials for Cerebrovascular Accident

Stroke in Young Fabry Patients (sifap1): Frequency of Fabry Disease in Young Stroke Patients

sifap1
Start date: January 2008
Phase:
Study type: Observational

More than one million people in Europe suffer from a stroke every day. Normally older people have a stroke, but also a significant number of younger people between 18 and 55 years. Usually, these cannot be explained by the classical risk factors such as diabetes, overweight and high blood pressure. New studies indicate that in about 1 - 2 % of the younger stroke patients the cause could have been an undiagnosed genetic disease, the so called Fabry disease. The purpose of this study is to determine in a large number of young stroke patients, how many strokes were caused by Fabry Disease.

NCT ID: NCT00414440 Completed - Clinical trials for Autosomal Dominant Polycystic Kidney Disease

Efficacy, Safety and Tolerability of Everolimus in Preventing End-stage Renal Disease in Patients With Autosomal Dominant Polycystic Kidney Disease

Start date: December 2006
Phase: Phase 4
Study type: Interventional

This study will assess whether everolimus (RAD001) is effective in preventing cyst and kidney expansion as well as worsening of renal function in patients with ADPKD and whether the application of 5 mg/day everolimus as monotherapy is safe and well tolerated.