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NCT ID: NCT01217944 Completed - Pathological Myopia Clinical Trials

Efficacy and Safety of Ranibizumab in Patients With Visual Impairment Due to Choroidal Neovascularization Secondary to Pathologic Myopia

Start date: October 2010
Phase: Phase 3
Study type: Interventional

This study is designed to evaluate the efficacy and safety of two different dosing regimens of 0.5 mg ranibizumab given as intravitreal injection in comparison to verteporfin PDT in patients with visual impairment due to choroidal neovascularization (CNV) secondary to pathologic myopia (PM).

NCT ID: NCT01216345 Completed - Locally Advanced Clinical Trials

Cetuximab + Gemox in Biliary Tract Cancer

Start date: October 2006
Phase: Phase 2
Study type: Interventional

The aim of this prospective single-centre phase II study is to investigate the therapeutic efficacy and safety of cetuximab in combination with Gemcitabine and Oxaliplatin (GEMOX) in the palliative first line treatment of biliary tract cancer (BTC) patients.

NCT ID: NCT01215955 Completed - Clinical trials for Diabetes Mellitus, Type 2

Study of Insulin Lispro in Participants With Inadequately Controlled Type 2 Diabetes

AUTONOMY
Start date: December 2010
Phase: Phase 4
Study type: Interventional

Evidence regarding optimal methods of insulin dose adjustment is lacking in the literature. The purpose of this study is to evaluate the efficacy and safety of two approaches to escalate prandial insulin therapy in participants with type 2 diabetes mellitus not achieving adequate glycemic control on basal insulin.

NCT ID: NCT01214720 Completed - Pancreatic Cancer Clinical Trials

A Study of Avastin (Bevacizumab) Added to a Chemotherapeutic Regimen in Patients With Metastatic Pancreatic Cancer

Start date: July 2005
Phase: Phase 3
Study type: Interventional

This study will evaluate efficacy, safety and tolerability of Avastin versus placebo added to a chemotherapeutic regimen in patients with metastatic pancreatic cancer. The anticipated time of study treatment is until confirmed evidence of disease progression, and the target sample size is 500+ individuals.

NCT ID: NCT01213836 Completed - Schizophrenia Clinical Trials

Compare the Effect on Cognitive Functioning of Two Formulations of Seroquel, Seroquel XR and IR in Patients With Stable Schizophrenia

eXtRa
Start date: November 2010
Phase: Phase 4
Study type: Interventional

This will be a phase IV 20 -32 day prospective, double blind, double-dummy, randomised crossover study that will evaluate the effect of quetiapine XR and quetiapine IR on cognitive performance in patients with schizophrenia stabilized on a single antipsychotic medication.

NCT ID: NCT01213641 Completed - Clinical trials for Cryopyrin-associated Periodic Syndromes (CAPS)

Clinical Outcomes and Safety: A Registry Study of Ilaris (Canakinumab) Patients

B-Confident
Start date: November 2009
Phase: N/A
Study type: Observational

The purpose of this observational study is to collect additional information regarding long-term safety and effectiveness of Ilaris in the treatment of CAPS patients in clinical practice.

NCT ID: NCT01213472 Completed - Melanoma Clinical Trials

Evaluation of a New Anti-cancer Immunotherapy in Patients With Non-operable and Progressing Metastatic Cutaneous Melanoma

Start date: January 31, 2011
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate the safety, immunogenicity and clinical activity of GSK2241658A antigen-specific cancer immunotherapeutic (ASCI) for the treatment of patients with non-operable and progressing metastatic cutaneous melanoma.

NCT ID: NCT01213407 Completed - Clinical trials for Glioblastoma Multiforme

Dendritic Cell Cancer Vaccine for High-grade Glioma

GBM-Vax
Start date: April 2010
Phase: Phase 2
Study type: Interventional

A randomised, open-label, 2-arm, multi-centre, phase II clinical study with one group receiving standard therapy with Temozolomide, radiotherapy, and Trivax; and a control group receiving standard therapy with Temozolomide and radiotherapy only; after tumour resection of at least 70% in both groups. The hypothesis is based on the assumption that time to progression will be doubled in the treatment group.

NCT ID: NCT01212991 Completed - Prostate Cancer Clinical Trials

A Safety and Efficacy Study of Oral MDV3100 in Chemotherapy-Naive Patients With Progressive Metastatic Prostate Cancer

PREVAIL
Start date: September 16, 2010
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the benefit of enzalutamide versus placebo as assessed by overall survival and progression-free survival in patients with progressive metastatic prostate cancer who have failed androgen deprivation therapy but not yet received chemotherapy.

NCT ID: NCT01211873 Completed - Clinical trials for Central Nervous System Diseases

Safety and Efficacy Evaluation of DOTAREM® in MRI of Central Nervous System (CNS) Lesions

SENTIO
Start date: September 2010
Phase: Phase 3
Study type: Interventional

The purpose of this study is to look at the safety (what are the side effects)and efficacy (how well does it work) of Dotarem® when used in taking images of the brain / spine. The results will be compared to the results of MRI taken without Dotarem.