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NCT ID: NCT02541227 Terminated - Ischemic Stroke Clinical Trials

Cerebrolysin REGistry Study in Stroke

CREGS-S
Start date: May 2014
Phase:
Study type: Observational [Patient Registry]

Investigation of clinical practices, safety and effectiveness of Cerebrolysin in routine treatment of patients with acute ischemic stroke.

NCT ID: NCT02524847 Terminated - Clinical trials for Steroid Refractory Acute Graft Versus Host Disease

Methoxsalen and Extracorporeal Photopheresis (ECP) for the Treatment of Pediatric Participants With Steroid Refractory Acute Graft Versus Host Disease

Start date: January 20, 2016
Phase: Phase 3
Study type: Interventional

This is a single-arm, open-label, multicenter study of the efficacy of UVADEX® (methoxsalen) Sterile Solution in conjunction with THERAKOS® CELLEX® Photopheresis Systems (ECP) in pediatric participants with steroid-refractory aGvHD. The study is composed of Screening, Treatment, and Follow-up Periods.

NCT ID: NCT02503527 Terminated - Clinical trials for Aneurysmal Subarachnoid Hemorrhage

Efficacy and Safety Study of a Low-carbohydrate Tube Feed in Critically Ill Patients Under Insulin Therapy

Start date: August 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the efficacy and safety of a diabetes-specific tube feed in comparison to an isocaloric, isonitrogenous standard enteral formula in critically ill patients receiving insulin treatment for blood glucose management.

NCT ID: NCT02494778 Terminated - Clinical trials for Huntington's Disease

A Study Evaluating if Pridopidine is Safe, Efficacious, and Tolerable in Patients With Huntington's Disease

Open PRIDE-HD
Start date: September 24, 2015
Phase: Phase 2
Study type: Interventional

The purpose of the study is to collect and assess long term data on the safety, tolerability, and efficacy of pridopidine in patients with Huntington's disease (HD).

NCT ID: NCT02492477 Terminated - Solid Tumours Clinical Trials

TOP-TRIAL Safety of Not Flushing Non-used PORT-A-CATH® in Cancer Patients

Start date: January 2016
Phase: Phase 1
Study type: Interventional

The benefits and risks of flushing or not flushing the non-used PORT-A-CATH® in cancer patients and the time interval of eventual PORT-A-CATH® flushing are currently unknown. The manufacturers of PORT-A-CATH® recommend regular flushings every 4 weeks. In clinical practice, the intervals are usually at least three months. Regular flushing might lead to a decreased risk of PORT-A-CATH® thrombosis, but may also lead to an increased infection or thrombosis rate and patients discomfort. Therefore, this study investigates the safety of not flushing the PORT-A-CATH® for 6 or 12 months.

NCT ID: NCT02483884 Terminated - Prostate Cancer Clinical Trials

PET/CT Imaging Study of the Safety and Diagnostic Performance of [68Ga]RM2 in Patients With Primary Prostate Cancer

Start date: May 2015
Phase: Phase 1/Phase 2
Study type: Interventional

The aim of this study is to investigate safety and diagnostic performance of the 68Ga labeled PET tracer [68Ga]RM2 for detection and localization of primary prostate cancer confirmed by histopathology of the prostate as a standard of truth. This is an open-label, multi center PET/CT (positron emission tomography/computed tomography) non-randomized study. The study comprises 2 parts with an interim analysis after Part 1. In Part 1 a total of 30 subjects with biopsy-proven primary prostate cancer will be enrolled. Three strata of patients for the first part will be enrolled based on their pretreatment recurrence risk assessment according to the NCCN guidelines: 10 patients with low, 10 patients with intermediate and 10 patients with high pretreatment risk of recurrence.

NCT ID: NCT02479386 Terminated - Geographic Atrophy Clinical Trials

A Study of Disease Progression in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Proxima A
Start date: June 24, 2015
Phase:
Study type: Observational

This study seeks to better characterize relationships between visual function and the progression (worsening) of geographic atrophy (GA) due to age-related macular degeneration (AMD). The study is also intended to generate new information on the relationship between genetics and GA progression. This is a global, prospective, multicenter, epidemiologic study enrolling participants with GA secondary to AMD. The study visits are scheduled to occur every 6 months. The anticipated duration of the study is up to 48 months. There is a planned interim analysis around the 2-year time window for the study.

NCT ID: NCT02477800 Terminated - Alzheimer's Disease Clinical Trials

221AD301 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease

ENGAGE
Start date: August 13, 2015
Phase: Phase 3
Study type: Interventional

The primary objective of the study is to evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) score as compared with placebo in participants with early AD. Secondary objectives are to assess the effect of monthly doses of aducanumab as compared with placebo on clinical progression as measured by Mini-Mental State Examination (MMSE), AD Assessment Scale-Cognitive Subscale (13 items) [ADAS-Cog 13], and AD Cooperative Study-Activities of Daily Living Inventory (Mild Cognitive Impairment version) [ADCS-ADL-MCI].

NCT ID: NCT02470312 Terminated - Heart Failure Clinical Trials

MediGuide Registry

Start date: August 18, 2015
Phase:
Study type: Observational [Patient Registry]

The goal of this registry/observational study is to collect data on the clinical utility of MediGuideā„¢ system in cardiac resynchronization therapy (CRT) implantation and electrophysiology (EP) procedures.

NCT ID: NCT02462538 Terminated - Clinical trials for ALK+ Anaplastic Large Cell Lymphoma

Brentuximab Vedotin and Imatinib in Patients With Relapsed or Refractory ALK+ ALCL

Start date: November 3, 2015
Phase: Phase 1/Phase 2
Study type: Interventional

This is an open label pilot study of combining BV in a licensed indication with imatinib in patients with ALCL. It is intended as a "window of opportunity" trial in which the study drugs will be given as an initial substitute for conventional chemotherapy with the intention to achieve a remission enabling the patients to proceed to autologous or allogeneic stem cell transplantation, if eligible.