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NCT ID: NCT00303589 Completed - Clinical trials for Soft Tissue Infections

A Study of Beta-Lactam in Hospitalized Patients With Skin and Skin Structure Infections

Start date: December 2005
Phase: Phase 2
Study type: Interventional

This 3 arm study will compare the efficacy and safety of beta-lactam with that of 'standard care' in patients with complicated skin and skin structure infections requiring hospitalization. Patients will be randomized to receive 1)beta-lactam 750mg iv q8h 2)beta-lactam 1500mg iv q8h or 3)'standard care' [PRP (nafcillin or flucloxacillin) or vancomycin, plus aztreonam or ciprofloxacin]. The anticipated time on study treatment is <3 months and the target sample size is 100-500 individuals.

NCT ID: NCT00303316 Completed - Hepatitis B Clinical Trials

Immunogenicity Study of Antibody Persistence and Booster Effect of PENTAXIM™ at 18 Months in Healthy Argentinean Infants

Start date: February 2006
Phase: Phase 3
Study type: Interventional

This study will assess both the antibody persistence of the investigational vaccine and the immune response and safety of a booster dose of PENTAXIM™ vaccine in 18 months-old toddlers who participated in an earlier study in order to determine if they are still protected before they receive a booster dose of D, T, IPV, pertussis or Hib vaccines and also to assess the quality of the induced immune memory in response to a booster dose of the same vaccine as in the primary series. Primary Objective: To describe the antibody persistence at 18 months of age and the booster effect of a dose of PENTAXIM™ on immunogenicity. Secondary objective: To describe the safety profile of the booster dose PENTAXIM™ in each vaccine group defined by the vaccines received during the primary series.

NCT ID: NCT00300885 Terminated - Clinical trials for Carcinoma, Non-Small Cell Lung

A Randomized Controlled Trial Comparing Safety and Efficacy of Carboplatin and Paclitaxel Plus or Minus Sorafenib (BAY 43-9006) in Chemonaive Patients With Stage IIIB-IV Non-Small Cell Lung Cancer (NSCLC)

Start date: February 2006
Phase: Phase 3
Study type: Interventional

A randomized controlled trial comparing safety and efficacy of carboplatin and paclitaxel plus or minus sorafenib in chemonaive patients with stage III-IV non-small cell lung cancer.

NCT ID: NCT00300274 Completed - Graft Rejection Clinical Trials

Efficacy and Safety of Everolimus in Recipients of Heart Transplants to Prevent Acute and Chronic Rejection

Start date: January 2006
Phase: Phase 3
Study type: Interventional

This trial was to examine the impact of everolimus and reduced dose of cyclosporine on efficacy and safety compared to mycophenolate mofetil and a standard dose of cyclosporine in heart transplant recipients.

NCT ID: NCT00297414 Completed - Clinical trials for Mild Cognitive Impairment

An Observational Study for Analysis of Mortality in Participants Who Participated in Previous 3 Studies of Galantamine

Start date: June 2004
Phase: Phase 3
Study type: Observational

The purpose of the study is to collect data of patients who were randomized (assignment of study medication by chance) and treated in 3 previous studies of galantamine (CR003145, CR002014 and CR005947) for the treatment of mild cognitive impairment (isolated memory impairment). This data were not recorded during the course of these 3 previous studies.

NCT ID: NCT00296855 Completed - Clinical trials for Peripheral Vascular Diseases

Comparison Study of Vasovist® Magnetic Resonance Angiography (MRA) and an MRA With a Conventional Extracellular Contrast Agent With X-ray Angiography in Patients With Peripheral Artery Disease

Start date: February 2006
Phase: Phase 3
Study type: Interventional

The particular aim of this study is the comparison of the diagnostic results of MRA images upon application of Vasovist (gadofosveset), a contrast agent not yet available on the market, with the MRA images upon application of a conventional extracellular contrast agent. A catheter angiography, which will be performed as a routine diagnostic procedure for vascular diseases, will serve as an evaluation standard.

NCT ID: NCT00296374 Completed - Diabetes Mellitus Clinical Trials

Prospective Evaluation of Proteinuria and Renal Function in Diabetic Patients With Progressive Renal Disease

PLANET 1
Start date: February 2006
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the effects of Crestor (rosuvastatin) and (Lipitor) atorvastatin on urinary protein excretion over 1 year in patients with Type 1 or 2 diabetes with moderate proteinuria and hypercholesterolaemia.

NCT ID: NCT00295633 Completed - Clinical trials for Diabetes Mellitus, Type 2

A Study Assessing Saxagliptin Treatment in Type 2 Diabetic Subjects Who Are Not Controlled With TZD Therapy Alone

Start date: March 2006
Phase: Phase 3
Study type: Interventional

The purpose of this clinical research study is to learn whether Saxagliptin added to thiazolidinedione (TZD) therapy is more effective than TZD alone as a treatment for Type 2 diabetic subjects who are not sufficiently controlled with TZD alone

NCT ID: NCT00294996 Active, not recruiting - Breast Cancer Clinical Trials

Trial of Myocet in Metastatic Breast Cancer

Start date: January 2006
Phase: Phase 3
Study type: Interventional

The purpose of the study is to examine the safety and effectiveness of the drug combination of Myocet, paclitaxel and trastuzumab compared to paclitaxel and trastuzumab without Myocet, as first line treatment for patients with metastatic HER2+ breast cancer.

NCT ID: NCT00294658 Active, not recruiting - Myasthenia Gravis Clinical Trials

Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy

Start date: June 2006
Phase: Phase 3
Study type: Interventional

The purpose of this trial is to determine if thymectomy combined with prednisone therapy is more beneficial in treating non-thymomatous myasthenia gravis than prednisone therapy alone.