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NCT ID: NCT00386360 Completed - Osteopenia Clinical Trials

Study of the Effect of Once a Week Risedronate on the Microstructure of Tibia and Radius Using a New Scanning Method

Start date: April 2006
Phase: Phase 3
Study type: Interventional

The primary purpose of the protocol is to evaluate the sensitivity of 3D-pQCT (3D-Peripheral Quantitative Computed Tomography) technology to detect minute changes in bone microarchitecture.

NCT ID: NCT00386100 Completed - Clinical trials for Diabetes Mellitus, Type 2

A Type 2 Diabetes Study of the Longer-Term Glycemic Effect of AVANDAMET vs. Metformin

Start date: October 2006
Phase: Phase 4
Study type: Interventional

This study will evaluate the longer-term glycemic effect of two medicines approved for initial treatment of type 2 diabetes. The study consists of a 2 week screening period (2 study visits), followed by an 80 week double-blind treatment period (11 study visits). Also, a sub-study was included to look at changes in bone mineral density (BMD) at the lumbar spine.

NCT ID: NCT00383422 Completed - Clinical trials for Osteoporosis, Postmenopausal

Study Comparing Arzoxifene With Raloxifene in Women After Menopause With Osteoporosis

Start date: October 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the effect of arzoxifene to raloxifene on the bone mineral density (bone strength).

NCT ID: NCT00381654 Terminated - Tumor Clinical Trials

Safety/Tolerability Study of AV-412 in Subjects With Refractory or Relapsed Solid Tumor Malignancies

Start date: October 2006
Phase: Phase 1
Study type: Interventional

AV-412 is a new oral therapy developed to inhibit the growth of solid tumors in patients who have not responded to standard therapy or surgical interventions, or who have experienced relapse. This study will test the safety of AV-412 and determine the maximum tolerated dose for the treatment of solid tumors.

NCT ID: NCT00379730 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Prednisolone Novel Endpoint Study in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Start date: March 21, 2006
Phase: Phase 1
Study type: Interventional

Prednisolone will be used as a model medication to identify new clinical outcomes for future evaluation of new therapies in short-term studies (up to 4 weeks) in patients with Chronic Obstructive Pulmonary Disease (COPD).

NCT ID: NCT00377637 Completed - Lupus Nephritis Clinical Trials

A Study of Mycophenolate Mofetil (CellCept) in Management of Patients With Lupus Nephritis.

Start date: July 2005
Phase: Phase 3
Study type: Interventional

This 2 arm study assessed the efficacy of Mycophenolate Mofetil (MMF; CellCept) compared to cyclophosphamide in inducing a response in patients with lupus nephritis, and the long term efficacy of MMF compared to azathioprine in maintaining remission and renal function. Patients were randomized to receive either MMF (1.5 g twice daily [bid]) or cyclophosphamide (0.5-1.0 g/m^2 in monthly pulses) in the induction phase. Those patients meeting criteria for response were re-randomized for entry into the maintenance phase, to receive either MMF (1 g bid) or azathioprine (2 mg/kg/day).

NCT ID: NCT00376337 Terminated - Clinical trials for Invasive Aspergillosis

Micafungin Salvage Mono-therapy in Invasive Aspergillosis

Start date: June 2006
Phase: Phase 2
Study type: Interventional

To evaluate the efficacy and safety of micafungin in patients with proven invasive aspergillosis and who are refractory or intolerant to previous systemic antifungal therapy. To compare the efficacy and safety of the micafungin therapy with the active control arm

NCT ID: NCT00376181 Terminated - Type 2 Diabetes Clinical Trials

Efficacy, Safety and Tolerability of Pioglitazone-Azilsartan in Subjects With Type 2 Diabetes Mellitus

Start date: June 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of pioglitazone-azilsartan, once daily (QD), in subjects with type 2 diabetes mellitus with poor glycemic control.

NCT ID: NCT00374322 Completed - Neoplasms, Breast Clinical Trials

Tykerb Evaluation After Chemotherapy (TEACH): Lapatinib Versus Placebo In Women With Early-Stage Breast Cancer

Start date: August 2006
Phase: Phase 3
Study type: Interventional

This study was designed to evaluate and compare the safety and efficacy of an oral dual tyrosine kinase inhibitor, lapatinib, versus placebo in women with early-stage ErbB2-overexpressing breast cancer who have completed their primary neoadjuvant or adjuvant chemotherapy and have no clinical or radiographic evidence of disease.

NCT ID: NCT00373425 Completed - Clinical trials for Non-small Cell Lung Cancer

A Study of Erlotinib (Tarceva) After Surgery With or Without Adjuvant Chemotherapy in Non-Small Cell Lung Carcinoma (NSCLC) Patients Who Have Epidermal Growth Factor Receptor (EGFR) Positive Tumors

RADIANT
Start date: September 2006
Phase: Phase 3
Study type: Interventional

This is a study to evaluate the effectiveness of erlotinib compared with a placebo sugar pill following complete surgical removal of the tumor with or without chemotherapy after surgery in Stage IB-IIIA NSCLC patients.