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NCT ID: NCT00856349 Completed - Clinical trials for Cardiovascular Disease

Medtronic Shock-Less Study on Physician Utilization of Shock Reduction Programming

Start date: April 2009
Phase: N/A
Study type: Observational

The purpose of this clinical trial is to determine whether periodic therapy programming reports illustrating physician usage of shock reduction programming can increase utilization of recommended programming guidelines for defibrillators.

NCT ID: NCT00856284 Completed - Clinical trials for Type 2 Diabetes Mellitus

Efficacy and Safety of Alogliptin Plus Metformin Compared to Glipizide Plus Metformin in Patients With Type 2 Diabetes Mellitus

ENDURE
Start date: March 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the safety and effectiveness of adding alogliptin, once daily (QD), compared to glipizide with metformin in diabetic patients.

NCT ID: NCT00855530 Completed - Clinical trials for Major Depressive Disorders

Long Term Safety and Tolerability of SR58611 in Patients With Major Depressive Disorder

Start date: September 2005
Phase: Phase 3
Study type: Interventional

Primary objective: - To evaluate the long-term safety and tolerability of SR58611A (amibegron) patients with major depressive disorder (MDD). Secondary objective: - To determine plasma concentrations of SR58878 (the active metabolite of SR58611A), for pharmacokinetic population analyses, to evaluate the quality of life (QoL) in patients with MDD, and to evaluate the efficacy of amibegron in patients with MDD.

NCT ID: NCT00855465 Completed - Clinical trials for Pulmonary Hypertension

A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With CTEPH.

CHEST-1
Start date: February 23, 2009
Phase: Phase 3
Study type: Interventional

The aim of the study is to assess the efficacy and safety of different doses of BAY63-2521, given orally for 16 weeks, in patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH).

NCT ID: NCT00853827 Completed - Clinical trials for Coronary Artery Disease (CAD)

Safety and Efficacy of Aliskiren on the Progression of Atherosclerosis in Coronary Artery Disease Patients

AQUARIUS
Start date: March 2009
Phase: Phase 3
Study type: Interventional

The study will assess the change in coronary atherosclerotic disease as determined by intravascular ultrasound (IVUS) for aliskiren compared to placebo when given in addition to standard therapy in patients with coronary artery disease (CAD) and a blood pressure in the pre-hypertensive range.

NCT ID: NCT00853658 Completed - Clinical trials for Chronic Heart Failure

Efficacy and Safety of Aliskiren and Aliskiren/Enalapril Combination on Morbi-mortality in Patients With Chronic Heart Failure

ATMOSPHERE
Start date: March 2009
Phase: Phase 3
Study type: Interventional

The study will evaluate the efficacy and safety of both aliskiren monotherapy and aliskiren/enalapril combination therapy as compared to enalapril monotherapy, on morbidity and mortality in patients with chronic heart failure (NYHA Class II - IV.

NCT ID: NCT00851045 Completed - Clinical trials for Colorectal Cancer (CRC)

Ph II Trial of a Novel Anti-angiogenic Agent in Combination With Chemotherapy for the Second-line Treatment of Metastatic Colorectal Cancer

Start date: October 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the efficacy of CT-322 comparative to bevacizumab, both in combination with irinotecan, 5-FU and leucovorin in the second-line treatment of subject with metastatic colorectal cancer

NCT ID: NCT00850330 Recruiting - Drug Interactions Clinical Trials

Study for Early Detection of Drug Interactions in Older Hospitalized Patients Using on Line Software

SEDDI
Start date: June 2009
Phase: N/A
Study type: Observational

A drug interaction (DI) is the mutual action of two drugs in a way that they can increase their action, even to a toxic level, or reduce it to its minimum. People elder than 65 years old have theirs biological ability to metabolized and eliminate drugs impaired. Even more, they tend to suffer from many diseases, are treated for many physicians, and receive many drugs for those conditions. If hospitalized older people are prone to receive a greater number of drugs. This scenario is the worst to suffer from adverse drug events and DI, which in turn compromise more the health and even life of hospitalized older people. Many computerized strategies have been developed to prevent those problems. In this trial the investigators use on line software to early detect DI that could endanger health or life of hospitalized older patients.

NCT ID: NCT00850252 Completed - Hemodialysis Clinical Trials

Use of a Lifeline Graft in the A-V Shunt Model

Start date: September 2004
Phase: Phase 1/Phase 2
Study type: Interventional

This study will assess the safety and efficacy of a completely autologous and completely biological tissue engineered blood vessel (TEBV) called Lifelineā„¢ used as an arteriovenous fistula for dialysis access.

NCT ID: NCT00850239 Terminated - Clinical trials for Type 2 Diabetes Mellitus

Safety and Efficacy Study of Dutogliptin/PHX1149T in Subjects With Type 2 Diabetes Mellitus on a Background Medication of Metformin

Start date: May 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to demonstrate the efficacy of dutogliptin over 26 weeks (as evidenced by placebo-corrected changes in HbA1c relative to baseline), to demonstrate safety and tolerability of dutogliptin, and to demonstrate changes in fasting plasma glucose over 26 weeks.