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NCT ID: NCT03803462 Recruiting - Behçet Disease Clinical Trials

Behçet's Disease Overall Damage Index

BODI
Start date: August 1, 2017
Phase:
Study type: Observational

Damage in vasculitis, as well as in other chronic inflammatory disorders, accrues over time resulting in impairment of quality of life, development of disability and increased mortality. For these reasons, damage represents an important outcome to be assessed and measured both in trials and clinical practice. Currently, the most widely used assessment tool for damage in vasculitis is the Vasculitis Damage Index (VDI). However, VDI was developed for a no specific type of vasculitis and it appears to be more suitable for damage assessment in ANCA-associated vasculitis than in Behçet' disease (BD). BD is a chronic and multisystem inflammatory disorder classified among vasculitides. As well as in other vasculitides, disease activity and treatment in BD can result in the development and accumulation of irreversible organ damage, such as blindness, tissue loss and a wide range of neurologic disorders. Recently the OMERACT has defined the Core Set domain of Outcome Measures for BD. Despite damage is included in the OMERACT outcome core set for rheumatic disease, a specific assessment tool for BD is currently not available. The aim of this study is to develop and validate the first tool for describing and measuring organ damage in patients with Behçet Disease (Behçet's disease Overall Damage index - BODI).

NCT ID: NCT03740880 Recruiting - Clinical trials for the Number of Mature Oocytes

Trigger Time in Advanced Maternal Age Patients With Low AMH

Start date: January 7, 2019
Phase: N/A
Study type: Interventional

The investigators want to verify if advanced maternal age patients with a low Anti-Müllerian hormone (AMH) level may benefit from an early trigger time (compared to a late trigger).

NCT ID: NCT03725969 Completed - Insulin Sensitivity Clinical Trials

Effect of Camel Milk on Insulin and Incretin Response

Start date: February 1, 2017
Phase: N/A
Study type: Interventional

To examine the differential effect of camel and cow milk on the physiological response, to a liquid mixed-meal challenge, in people with normal glucose tolerance

NCT ID: NCT03724136 Recruiting - Alzheimer Disease Clinical Trials

Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study

ACIST
Start date: October 24, 2018
Phase: N/A
Study type: Interventional

The purpose of the study is to evaluate the use of autologous Bone Marrow Derived Stem Cells (BMSC) as a means to improve cognitive impairment as occurs in Alzheimer's Disease and other dementias and to improve behavior and socialization issues which occur in adult Autism Spectrum Disorder. The use of Near Infrared Light, in conjunction with the use of BMSC, will also be assessed.

NCT ID: NCT03708991 Recruiting - Genetic Condition Clinical Trials

Effectiveness of PGT-A: IVF Versus ICSI

Start date: November 8, 2018
Phase:
Study type: Observational [Patient Registry]

The investigators want to investigate if the use of conventional in vitro fertilization (IVF) can generate more euploid embryos as compared to intracytoplasmic sperm injection (ICSI). To verify this, the investigators will inject half of the oocytes by ICSI and the other half of the oocytes will be inseminated by conventional IVF. The most important aim is to see if IVF is able to generate more euploid embryos.

NCT ID: NCT03703869 Recruiting - Diabetes Clinical Trials

Twelve -Month Study Observing How Insulin-naïve Patients With Type 2 Diabetes Mellitus Manage Diabetes Using Toujeo® After Oral Antidiabetic Drug Failure, the Side Effect of Toujeo®, and The Cost.

ATOS
Start date: March 6, 2018
Phase:
Study type: Observational

Primary Objective: Assess effectiveness of insulin glargine (U300) in achieving glycemic goal measured by hemoglobin A1c (HbA1c). Secondary Objectives: - Assess effectiveness in achieving glycemic goal measured by HbA1c; - Assess effectiveness on change in HbA1c, fasting plasma glucose (FPG) and self-monitored plasma glucose (SMPG) ; - Assess requirement for intensification of therapy by additional antidiabetics. - Assess incidence of hypoglycemia; - Assess other safety endpoints: adverse events (AEs), serious adverse events (SAEs); - Assess change in body weight.

NCT ID: NCT03686059 Recruiting - Clinical trials for Ocular Surface Disease

Outcome of Punctal Plugs on Ocular Surface Disease

Start date: July 2, 2018
Phase: Phase 4
Study type: Interventional

Ocular surface disease is a common adverse effect of systemic isotretinoin therapy. The investigators consider that punctal plugs is simple procedure with good patient compliance for treatment of ocular surface disease associated with systemic isotretinoin therapy

NCT ID: NCT03644459 Not yet recruiting - Colorectal Cancer Clinical Trials

Safety and Efficacy of the Fully Humanized Anti - VEGF Monoclonal Antibody LYN00101

Start date: October 2, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is evaluate the pharmacokinetics, pharmacodynamics, immunogenicity and anti-tumor effect of of fully human anti - VEGF monoclonal antibody LY00101 and explore the potential prognostic and predictive biomarkers. This study will not take into account the results of molecular-genetic tests of patients enrolled in the study

NCT ID: NCT03636464 Recruiting - Clinical trials for Renal Replacement Therapy

Pharmacokinetics of Antibiotics in Patients Undergoing Renal Replacement Therapies

RRTdose
Start date: April 1, 2018
Phase:
Study type: Observational

The study is aiming to describe the pharmacokinetic and pharmacodynamic profile of intravenous meropenem, ertapenem, cefepime, colistin, Ceftazidime/Avibactam , Ceftolozane/Tazobactam , and piperacillin/tazobactam in the plasma and determine how much is removed by Renal Replacement Therapies to ensure adequate dosing

NCT ID: NCT03607604 Active, not recruiting - Clinical trials for Diabetes Mellitus, Type 2

Application of UCPCR as a Testing Tool for Identification of MODY Patients in the UAE

Start date: April 1, 2015
Phase:
Study type: Observational

The study aims to investigate the validity of 2 hour post-prandial UCPCR test in paediatric and adult patients with diabetes duration greater than 2 and 5 years, respectively, for the purposes of distinguishing between patients with type 1 diabetes and MODY in the UAE population.