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NCT ID: NCT03644459 Not yet recruiting - Colorectal Cancer Clinical Trials

Safety and Efficacy of the Fully Humanized Anti - VEGF Monoclonal Antibody LYN00101

Start date: October 2, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is evaluate the pharmacokinetics, pharmacodynamics, immunogenicity and anti-tumor effect of of fully human anti - VEGF monoclonal antibody LY00101 and explore the potential prognostic and predictive biomarkers. This study will not take into account the results of molecular-genetic tests of patients enrolled in the study

NCT ID: NCT03636464 Recruiting - Clinical trials for Renal Replacement Therapy

Pharmacokinetics of Antibiotics in Patients Undergoing Renal Replacement Therapies

Start date: April 1, 2018
Study type: Observational

The study is aiming to describe the pharmacokinetic and pharmacodynamic profile of intravenous meropenem, ertapenem, cefepime, colistin, Ceftazidime/Avibactam , Ceftolozane/Tazobactam , and piperacillin/tazobactam in the plasma and determine how much is removed by Renal Replacement Therapies to ensure adequate dosing

NCT ID: NCT03607604 Active, not recruiting - Clinical trials for Diabetes Mellitus, Type 2

Application of UCPCR as a Testing Tool for Identification of MODY Patients in the UAE

Start date: April 1, 2015
Study type: Observational

The study aims to investigate the validity of 2 hour post-prandial UCPCR test in paediatric and adult patients with diabetes duration greater than 2 and 5 years, respectively, for the purposes of distinguishing between patients with type 1 diabetes and MODY in the UAE population.

NCT ID: NCT03607409 Recruiting - Infertility Clinical Trials

Role of Inhibin A as Biomarker for Ovarian Response for IVF Treatment

Start date: September 9, 2018
Study type: Observational

To evaluate the role of Inhibin A as bio marker for the number of mature oocytes, compared to Estradiol

NCT ID: NCT03597958 Recruiting - Clinical trials for Familial Hypercholesterolemia

Genetic Causes of Hypercholesterolaemia in the Emirati Population

Start date: January 17, 2017
Study type: Observational

The scientific aims of the project are to understand the genetic basis of Familial Hypercholesterolaemia (FH) in the Emirati population and estimate the overall prevalence of the disease. In addition, a clinical aim of the project is to explore the effectiveness of screening the relatives of individuals affected by FH and other lipid disorders ("cascade" screening) within Emirati families.

NCT ID: NCT03590587 Recruiting - Clinical trials for Diabetic Macular Edema

Rapid Structural and Functional Improvements in Following 0.19 mg Fluocinolone Acetonide (FAc) Implant in Diabetic Macular Edema Patients With Poor Visual Acuity: 12-month Audit Results From United Arab Emirates

Start date: January 13, 2017
Study type: Observational

The Health Authority - Abu Dhabi (HAAD) approved the reimbursement of the slow release FAc implant (ILUVIEN) and it is now available for the treatment of diabetic macular edema (DME) in persons who have been previously treated with a course of corticosteroids and did not have a clinically significant rise in intraocular pressure. We performed a retrospective 12-month audit to assess the efficacy and safety of the FAc implant in our clinical practice.

NCT ID: NCT03589092 Recruiting - Clinical trials for Gestational Diabetes

Genetic Causes of Gestational Diabetes in the Emirati Population

Start date: January 1, 2017
Study type: Observational

The study aims to identify the number of MODY patients to be found among Emirati women with GDM as the incidence and prevalence of monogenic diabetes among this group of patients is unknown. This will enable improvements in diagnostics, treatment and the counselling of these women.

NCT ID: NCT03589079 Recruiting - Genetic Disorder Clinical Trials

Delineation of Novel Monogenic Disorders in the United Arab Emirates Population

Start date: January 1, 2018
Study type: Observational

The study aims to identify novel monogenic phenotypes from specific pedigrees and discover the underlying causal genetic variant using genetic sequencing (Sanger and/or Next Generation Sequencing - Panel/WES/WGS) methodologies in families across the United Arab Emirates (UAE).

NCT ID: NCT03584191 Enrolling by invitation - Obesity Clinical Trials

Awareness, Care & Treatment In Obesity Management - An International Observation

Start date: June 4, 2018
Study type: Observational

The purpose of this survey is to collect the data on perceptions, behaviours and awareness related to obesity and obesity management for People with Obesity (PwO) and Health Care Professionals (HCP) treating obesity. Data will be collected via online surveys among each of the respondent groups. The surveys are expected to take approximately 25 minutes to complete and will be unique for PwO and HCP. As a cross-sectional study, there will be no treatment of patients.

NCT ID: NCT03578094 Completed - Clinical trials for Adiposity, Breast Feeding

Mother and Infant Study Cohort (MISC)-

Start date: December 1, 2015
Study type: Observational

This study aims to explore breastfeeding and complementary feeding practices of mothers in the United Arab Emirates (UAE) and its relation to the early life determinants of obesity and non-communicable diseases (NCDs). This research study will follow a prospective cohort approach. Two hundred and fifty mother-infant pairs will be followed for 18 months. The hypothesis of this research study is that exclusive breastfeeding of the infant will provide potential protective effect against cardiometabolic risk factors. This study will also hypothesize that mothers who exclusively breastfeed their newborns would experience greater postpartum weight and body fat loss than mothers who are not breastfeeding.