Coronary Artery Disease Clinical Trial
Official title:
Evaluation of Demographic Variables, Clinical Parameters, Inflammatory Markers and Viruses in Periodontitis Patients With Coronary Artery Diseases
To assess and compare the demographic variables, periodontal parameters, cardiac parameters and the expression of periodontal viruses (CMV, HSV and EBV) and inflammatory biomarkers(PTX-3, TLR-2 & TLR-4) in periodontally healthy and generalized periodontitis patients with and without coronary artery disease(CAD).
A total of 240 subjects will be recruited based on the power of the study. The selected
subjects will be divided into four groups based on the inclusion and exclusion criteria.
1. GROUP I: 60 healthy subjects ( No generalised periodontitis and no CAD)
2. GROUP II: 60 generalised periodontitis subjects without CAD
3. GROUP III: 60 CAD subjects without generalised periodontitis
4. GROUP IV: 60 subjects with Generalised periodontitis and CAD
Sub-gingival plaque samples will be collected from the subjects of all the four groups.
Coronary artery plaque samples will be collected from the patients who were indicated for
coronary artery bypass graft surgery (CABG) among group III and group IV.
The demographic variables , periodontal parameters , cardiac parameters , expression of
periodontal viruses and inflammatory biomarkers will be measured in all four groups ,
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