Coronary Artery Disease Clinical Trial
Official title:
Relationship Between Heme Oxygenase 1 Enzyme Level and SYNTAX Score in Patients With Stable Coronary Artery Disease
Aim of this study is to investigate the relationship between heme oxygenase-1 enzyme level and angiographically determined SYNTAX score in patients with suspected stable coronary artery disease. Consecutive patients who are deemed to undergo coronary angiography due to high pre test probability or evidence of cardiac ischemia in imaging studies will be included in the study. Patients with coronary artery bypass surgery history and severe comorbid illnesses such as active malignancy, chronic obstructive lung disease, stage 3-5 chronic renal failure will be excluded. Serum heme oxygenase levels will be measured by ELISA method and SYNTAX score will be calculated from coronary angiography.
Heme oxygenase-1(HO-1) is an enzyme found throughout the body with highest concentrations in
tissues of reticuloendothelial system. It degrades heme to biliverdin and produces ferrous
iron and carbon monoxide. It is an inducible anti oxidant enzyme production of which
increases during high levels of oxidative stress. Synthesis of HO-1 is regulated mainly on
transcriptional level.
Coronary artery disease is characterized by high oxidative stress levels. Initiation of
atherosclerosis as well as progression and vulnerable plaque formation are shown to be linked
to oxidation-anti oxidation imbalance.
Several studies showed a correlation between heme oxygenase-1 level, activity and coronary
artery disease. Measuring heme oxygenase-1 activity from peripheral blood samples is
technically challenging. Bilirubin levels are used as a marker of heme oxygenase activity and
are showed to be related to coronary artery disease. As previously mentioned HO-1 is an
inducible enzyme so the increased levels reveal a high oxidative stress situation. High
levels of serum HO-1 are found also in other clinical settings such as interstitial
pneumonia, malignancies, acute kidney injury.
Burden of coronary artery disease is highly correlated with adverse prognosis in patients
with stable coronary artery disease and acute coronary syndrome. SYNTAX score is a well
established tool to determine the extent of coronary artery disease. Severity and location of
coronary stenoses as well as calcification and morphology are considered in SYNTAX score.
Clinical SYNTAX score also incorporates clinical characteristics of patients including age,
creatinine clearance, diabetes etc. High SYNTAX score is associated with increased total and
cardiovascular mortality.
The aim of this study is to investigate serum heme oxygenase-1 level and SYNTAX score in
patients with suspected coronary artery disease. Patients will be recruited from a single
center consecutively. Blood samples will be drawn before coronary angiography. SYNTAX score
will be calculated for each patient. Demographical and clinical characteristics of patients
will also be recorded. Patients without coronary artery disease will be used as control
group. Primary outcome measure will be to determine the relationship between HO-1 levels and
SYNTAX score.
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