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Oxidative Stress clinical trials

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NCT ID: NCT03952000 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

Influence of Prior Walking on Postprandial Metabolism in Centrally Obese Men

Start date: January 3, 2019
Phase: N/A
Study type: Interventional

The present study will investigate the effect of prior walking on postprandial metabolism and endothelial function in centrally obese South Asian and White European men. Participants will complete two, 2-day trials in a random, crossover design separated by at least a week. On day 1, participants will either rest or complete a 60 minute walk at 60% maximal oxygen uptake. On day 2, participants will arrive at 08:00 having fasted overnight and a baseline venous blood sample and endothelial function measurement will be taken. Participants will consume a high-fat breakfast and lunch and 12 subsequent venous blood samples will be taken throughout the day at standardised intervals to measure a variety of coronary heart disease risk markers. A second endothelial function measurement will be completed 2 hours after the breakfast. Blood pressure will be measured every hour. It is expected that the South Asian participants will have impaired metabolism and endothelial function compared to their European counterparts but the bout of exercise performed on day 1 will mitigate these responses.

NCT ID: NCT03948737 Completed - Oxidative Stress Clinical Trials

The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell Membrane Beta-thalassemia Major

Start date: December 30, 2016
Phase: N/A
Study type: Interventional

The accumulation of unpaired α-globin chains in β-thalassemia major patients may clinically create ineffective erythropoiesis, hemolysis, and chronic anemia. Multiple blood transfusions and iron overload cause cellular oxidative damage. However, α-tocopherol, an antioxidant, has been known as a potent scavenger of lipid radicals in the red cell membrane of β-thalassemia major patient. By this randomized controlled trial, the investigators would like to evaluate the effects of α-tocopherol in hemolysis and oxidative stress on the red cell membrane of β-thalassemia major.

NCT ID: NCT03945955 Not yet recruiting - Oxidative Stress Clinical Trials

Melatonin and DNA Damage Study

Start date: July 2019
Phase: Phase 4
Study type: Interventional

This research aims to determine if melatonin supplementation, through improvements in sleep quality, increases the ability to repair oxidative DNA damage and reduce lipid peroxidation levels among nightshift workers.

NCT ID: NCT03945526 Completed - Oxidative Stress Clinical Trials

Effect of Astaxanthin Supplementation on Plasma Malondialdehyde Levels and NIHSS of Stroke Patients

Start date: March 23, 2010
Phase: Phase 1
Study type: Interventional

This is an interventional randomized, controlled trial in analyzing the effects of astaxanthin supplementation on plasma malondialdehyde levels and NIHSS of acute ischemic stroke patients. According to published studies, it was hypothesized that acute ischemic stroke patients who were given astaxanthin would have lower plasma malondialdehyde levels and lower NIHSS score compared to the control group.

NCT ID: NCT03938584 Recruiting - Inflammation Clinical Trials

The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients

Start date: October 12, 2017
Phase: N/A
Study type: Interventional

The goal of this study is to perform a randomized clinical trial to assess the effects of vitamin C versus placebo on wound healing in mandibular fracture patients.

NCT ID: NCT03899454 Not yet recruiting - Oxidative Stress Clinical Trials

Garcinia Mangostana L Rind and Solanum Lycopersicum Fructus Trial to Prevent Exercise-induced Oxidative Stress

GMR-RCT-EOS
Start date: April 15, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

Treatments are an administration of a mixed extract of Garcinia mangostana 400mg and Solanum Lycopersicum Fructus 200mg (OKSI(R) POM TR 193324351) and placebo control.

NCT ID: NCT03893864 Completed - Aging Clinical Trials

Bioavailability and Impact of Coenzyme Q10 in Stressing Exercise in Senescence Athletes

CoQ10Sport
Start date: March 1, 2018
Phase: Phase 1
Study type: Interventional

It is proposed to establish a group of subjects composed of 10 healthy individuals of> 50 years and <65, physically active, without metabolic or inflammatory pathology. All of them will undergo a health examination and the physical condition and the absence of contraindication of the sports practice will be characterized through a monitored effort test. Each subject will take a capsule of coenzyme Q10® INDENA for 30 days. The dose to be administered is 100 mg/d of CoQ10 a with food (noon). The state of physical condition and the biochemical and biological variables that reflect oxidative stress and mitochondrial functioning before and after the intervention will be measured.

NCT ID: NCT03821116 Recruiting - Inflammation Clinical Trials

Milk and Soured Milk (filmjölk) Intervention on Oxidative Stress and Inflammation

Start date: January 7, 2019
Phase: N/A
Study type: Interventional

This study evaluates a high intake of milk compared with a high intake of soured milk (Swedish filmjölk) on markers of oxidative stress and inflammation in a randomized crossover intervention study.

NCT ID: NCT03820245 Completed - Atherosclerosis Clinical Trials

Effect of Short-term Annatto Carotenoids Supplementation on Oxidative Stress Status in Healthy Individuals

Start date: August 24, 2016
Phase: N/A
Study type: Interventional

Low-density lipoprotein (LDL) oxidation has a pivotal role in atherosclerosis development. There is a relationship between carotenoids serum concentration and cardiovascular (CV) benefits, mainly in oxidized LDL (oxLDL) reduction. Despite cardio protective effects of annatto carotenoids, bixin and norbixin, in vitro and in animal studies, its short or long-term supplementation effect on humans are not know. Objective: To analyse CV benefits of annatto carotenoids short-term supplementation in healthy individuals, comparing to lycopene effect. Methods: 16 healthy volunteers (8 men and 8 women) consumed 0.5 mg/kg b.w. of each treatment (bixin, norbixin, lycopene or placebo) through capsules, during 7 days. It was analysed the susceptibility of LDL to Cu2+-induced oxidation, biochemical parameters and oxidative stress biomarkers at the beginning and end of each treatment.

NCT ID: NCT03814577 Enrolling by invitation - Morbid Obesity Clinical Trials

A Comparison of the Effects of Desflurane and TIVA on Antioxidant System in Morbidly Obese Patients

OxSys
Start date: January 24, 2019
Phase: N/A
Study type: Interventional

With the development of technology, the safety of anesthesia devices and the progression of monitoring techniques affect the anesthetic management. There are some disadvantages such as high cost of inhalation anesthetics and long postoperative recovery time. The effects of total intravenous anesthesia (TIVA), which has been used for many years and whose positive aspects are well known, on antioxidant system in high risk patients such as morbid obese should be investigated. The aim of this study was to compare the effects of desflurane anesthesia and total intravenous anesthesia (TIVA) on the antioxidant system in morbidly obese patients undergoing bariatric surgery.