Parasternal Nerve Block in Cardiac Patients

Status Completed

Clinical Trial Summary

Exparel is a new local analgesic (numbing medication) that is intended to be longer acting than currently available local analgesics. The purpose of this study is to determine whether use of Exparel to numb the nerves along the breastbone after open heart surgery, will decrease pain and pain medication use after surgery.

Clinical Trial Description

This is a Phase 2, single-institution, randomized, double-blind, parallel-group, placebo-controlled trial of patients undergoing a median sternotomy for primary cardiopulmonary bypass grafting (CABG) surgery.

78 subjects (39 per treatment arm) will be randomized in a 1:1 ratio to receive a single-dose, parasternal nerve block with either 266 mg Exparel or placebo (0.9% normal saline solution). The nerve blocks will be performed under direct visualization at the end of surgery, just prior to sternal closure. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01826851
Study type	Interventional
Source	University of Rochester
Contact
Status	Completed
Phase	Phase 2
Start date	March 2013
Completion date	June 2017

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