Coronary Artery Disease Clinical Trial
Official title:
Effects of Exercise Training on Endothelial Function, Inflammation, Arterial Stiffness and Autonomic Function in Coronary Artery Disease Patients
The main purposes of this study is to analyze, in a randomized controlled trial, the effects
of an exercise-based cardiac rehabilitation program (i) on biomarkers of endothelial
function, (ii) on biomarkers of inflammation, (iii) on autonomic function, and (iv) on
arterial stiffness in coronary artery disease patients (CAD). Additionally, the
investigators aim to analyze the (v) contribution of age and the changes in traditional risk
factors to the modification of the endothelial dysfunction and inflammation, and (vi) the
contribution of the changes in inflammatory and endothelial function biomarkers to the
modification of autonomic function and arterial stiffness.
The investigators hypothesize that exercise training will improve the autonomic function,
arterial stiffness and mitigate the endothelial dysfunction and inflammation in CAD patients
even in the absence of significant changes in traditional risk factors. Thus, the
investigators expect with the present study to promote, develop and expand the knowledge in
this field by assessing the impact of exercise on a pool of markers that provide a wide
picture of the pathophysiological processes underlying CAD.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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