Coronary Artery Disease Clinical Trial
Official title:
The Association Between Platelet Function and Endothelial Function of the Brachial Artery in Healthy Subjects and in Patients With Coronary Artery Disease
The proposed study is a prospective one, and will be held on consecutive individuals undergoing the non-invasive brachial artery flow-mediated dilation (FMD) ultrasound for endothelial function at the endothelial function laboratory of the Sheba Medical Center. The study group will be divided into healthy subjects group and coronary artery disease (CAD) patients group, both of which will be analyzed in respect to age, cardiovascular risk factors and the results of the platelet and endothelial functions tests. The association between platelet and endothelial functions will be then assessed in the healthy subjects group and in the CAD patients group.
Background: Previous studies have shown a significant association between endothelial
dysfunction and CAD and cardiovascular risk factors. Since the endothelium is a systemic
organ, endothelial dysfunction is a systemic vascular disorder which bring about a reduction
in nitric oxide (NO) bioavailability accounting for distraction of the platelet function.
Thus, we expect to find an association between platelet function and endothelial function
assessed by the brachial artery FMD in healthy subjects and in CAD patients. Moreover, as
platelet function, normally blocked by an effective anti-thrombotic therapy, is linked to
the progression of atherosclerosis which, by itself is an influential process on endothelial
function, we expect to find an association between endothelial function and the success of
anti-thrombotic therapy.
Aim: To determine the association between platelet function and endothelial function
assessed by brachial artery FMD in healthy subjects and in CAD patients, and to determine
the association between anti-thrombotic therapy and endothelial function.
Methods: The proposed study is a prospective one, and will be held on consecutive
individuals undergoing the non-invasive brachial artery flow-mediated dilation (FMD)
ultrasound for endothelial function at the endothelial function laboratory of the Sheba
Medical Center. The study group will be divided into healthy subjects group and coronary
artery disease (CAD) patients group, both of which will be analyzed in respect to age,
cardiovascular risk factors and the results of the platelet and endothelial functions tests.
The association between platelet and endothelial functions will be then assessed in the
healthy subjects group and in the CAD patients group.
The assessment of endothelial function is relatively simple and non-invasive method of short
duration. Implementing this simple method to comprehend the platelet function will enable
clinicians to better monitor and control the platelet inhibition in healthy subjects (for
primary prevention) and in CAD patients (for secondary prevention). In addition, the FMD
method can be useful in the evaluation of the success of the (antithrombocytic) treatment,
the prognosis and the risk-stratification in hospitalized patients with acute coronary
syndromes.
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Observational Model: Cohort, Time Perspective: Prospective
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