Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
The area under the curve of baseline blood pressure |
The area under the curve (AUC) of blood pressure below baseline mean arterial pressure within 3 minutes to 15 minutes after endotracheal intubation |
From 3 minutes after endotracheal intubation(T1) to 15 minutes after endotracheal intubation(T2). T1 is defined as 3 minutes after endotracheal intubation. T2 is defined as 15 minutes after endotracheal intubation. It will take up to 1hour or 2hours. |
|
Secondary |
The area under the curve of baseline blood pressure |
AUC above baseline MAP (MAP-time integral) and below baseline MAP (MAP-time integral) |
From from the beginning of the general anaesthesia induction(T1) to 3 minutes after endotracheal intubation(T2). T1 is when midazolam is administered. T2 is defined as 3 minutes after endotracheal intubation. It will take up to 1hour or 2hours. |
|
Secondary |
The highest and lowest values of arterial blood pressure |
The highest and lowest values of arterial blood pressure (SBP, DBP, MAP) |
From the beginning of the general anaesthesia induction(T1) to 15 minutes after endotracheal intubation(T2). T1 is when midazolam is administered. T2 is defined as 15 minutes after endotracheal intubation. It will take up to 1hour or 2hours. |
|
Secondary |
The types of vasoactive drugs used. |
The types of vasoactive drugs used ,such as the use of norepinephrine and dopamine. |
From the beginning of the general anaesthesia induction(T1) to 15 minutes after endotracheal intubation(T2). T1 is when midazolam is administered. T2 is defined as 15 minutes after endotracheal intubation. It will take up to 1hour or 2hours. |
|
Secondary |
The frequency of vasoactive drugs used. |
The frequency of vasoactive drugs used ,such as the use of norepinephrine and dopamine. |
From the beginning of the general anaesthesia induction(T1) to 15 minutes after endotracheal intubation(T2). T1 is when midazolam is administered. T2 is defined as 15 minutes after endotracheal intubation. It will take up to 1hour or 2hours. |
|
Secondary |
The incidence of arrhythmias. |
The incidence of arrhythmias, such as atrioventricular block, atrial fibrillation, ventricular tachycardia and so on. |
From the beginning of the general anaesthesia induction(T1) to 15 minutes after endotracheal intubation(T2). T1 is when midazolam is administered. T2 is defined as 15 minutes after endotracheal intubation. It will take up to 1hour or 2hours. |
|
Secondary |
cardiac systolic function:Left Ventricular Ejection Fraction (LVEF) |
Left ventricular ejection fraction,a parameter of left ventricular systolic function. left ventricular ejection fraction (LVEF) (?)= stroke output (SV)/ left ventricular end-diastolic volume (LEDV)×100?,will be evaluated before induction of anesthesia and after central venous catheterization. |
Beginning of the general anaesthesia induction(T1) is when midazolam is administered. T2 is when central venous catheterization is finished. It will take up to 1hour or 2hours. |
|
Secondary |
cardiac diastolic function:E/E' (the ratio of E peak and E') or E/A :(the ratio of E peak and A peak) |
E/A ratio, one of the main parameter for evaluating diastolic function, indicated normal diastolic function when E/A >1, and decreased diastolic function when E/A < 1.It will be evaluated before induction of anesthesia(T1) and after central venous catheterization(T2). |
Beginning of the general anaesthesia induction(T1) is when midazolam is administered. T2 is when central venous catheterization is finished. It will take up to 1hour or 2hours. |
|
Secondary |
tricuspid annular plane systolic excursion(TAPSE) |
Tricuspid annular plane systolic excursion is a reliable indicator of right ventricular systolic function.It represents the longitudinal function of the RV and it should be measured in the apical four-chamber projection using one-dimensional echocardiography (M-mode) at the peak excursion of the tricuspid annulus (expressed in millimeters) from the end of diastole to the end of systole.It will be evaluated before induction of anesthesia(T1) and after central venous catheterization(T2). |
Beginning of the general anaesthesia induction(T1) is when midazolam is administered. T2 is when central venous catheterization is finished. It will take up to 1hour or 2hours. |
|
Secondary |
Respiratory variation in inferior vena cava diameter (DIVC) |
Respiratory variation in inferior vena cava diameter (DIVC) is a measure of capacity load.DIVC=(Maximum diameter of inferior vena cava - minimum diameter of inferior vena cava) ÷ maximum diameter of inferior vena cava |
Beginning of the general anaesthesia induction(T1) is when midazolam is administered. T2 is when central venous catheterization is finished. It will take up to 1hour or 2hours. |
|
Secondary |
The number of patients with postoperative hoarseness. |
Hoarseness was classified as mild, moderate and severe according to the severity. |
Three days after the surgery |
|
Secondary |
The number of patients with postoperative sore throat. |
Sore throats can be evaluated using the Numeric Pain Scale (NRS) pain numerical score(0-10 score, 0: no pain, 10: worst imaginable pain). |
Three days after the surgery |
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