Congestive Heart Failure Clinical Trial
Official title:
Genetic Risk Assessment of Defibrillator Events: A Prospective Multicenter Observational Study
Arrhythmias remain a major health problem, causing at least 250,000 deaths annually in the
United States. Pharmacological treatments often do more harm than good, and device therapies
are limited by high cost and effects on quality of life. Ion channel mutations cause rare
inherited arrhythmopathies, but account for only a small fraction of patients with life-
threatening arrhythmias and sudden death. Most arrhythmias occur during myocardial ischemia,
following myocardial infarction, and in patients with poor left ventricular (LV) function of
any etiology. Aside from ejection fraction (EF), few clinically useful indicators to
stratify the risk of sudden death have been identified. The role of subtle difference in ion
channel expression and/or structure in predisposing patients to arrhythmias and modulating
the risk of sudden death is unknown.
In this study, we are prospectively testing whether polymorphisms in ion channels and ion
channel modifying genes are associated with arrhythmias in a population with internal
cardioverter-defibrillators (ICDs) and poor LV function. We will test the hypothesis that
functional polymorphisms in the coding sequences and promoter regions of cardiac genes (e.g.
ion channels, beta-adrenergic receptors) predispose individuals to arrhythmias and /or heart
failure progression.
We hope to identify genetic predictors for the common forms of sudden cardiac death. This
would allow the identification of a subpopulation of heart failure patients that would
benefit most from ICD placement.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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