Childhood Obesity Clinical Trial
Official title:
Genetic Determinants and Clinical Consequences of Early-onset Severe Obesity
The aim of the present study is to identify new obesity-related genetic defects and determine their association with clinical manifestations in families with childhood-onset severe obesity. The investigators hypothesize that by exploring children with severe early-onset obesity they can find new obesity-related genetic defects and by exploring obesity-associated clinical manifestations the investigators can elucidate the outcomes of severe childhood obesity.
Obesity is a complex disorder with many contributing genetic and environmental factors. The genetic causes and mechanisms for severe childhood obesity are still incompletely understood. It is acknowledged that obesity in some individuals could be a consequence of rare genetic variants with strong effect - these rare variants might be population specific. The aims of this study are to determine - inheritance patterns of early-onset obesity - new obesity-related genetic variants and disease-causing gene mutations - the association between obesity-related genetic defects and clinical manifestations - the association between obesity-related genetic defects and psychiatric symptoms in patients with early-onset obesity and their first-degree relatives Significant advancements in genetic methodology provide new tools to explore genetic defects underlying obesity. Family-based approach provides several advantages compared to cohort studies to investigate genetic determinants of complex diseases.The unique genetic composition of the Finnish population enables identification of novel genetic entities. Discovery of genetic defects associated with severe childhood-onset obesity will increase the investigators understanding of the pathogenesis of obesity and allows early detection, by genetic testing, of those at increased risk and optimal targeting of preventive measures. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05437406 -
Family, Responsibility, Education, Support, and Health for Latino Caregivers (FRESH-LC)
|
N/A | |
| Completed |
NCT03297541 -
Healthy Kids I-PAL
|
N/A | |
| Completed |
NCT05527938 -
Web-based Interventions on Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Children
|
N/A | |
| Completed |
NCT05501392 -
South Texas Early Prevention Studies PreK
|
N/A | |
| Completed |
NCT03334266 -
Preventing Early Childhood Obesity, Part 2: Family Spirit Nurture, Prenatal - 18 Months
|
N/A | |
| Active, not recruiting |
NCT03342092 -
Early Adiposity Rebound Amongst 4-y.o. Children and Overweight Risk Amongst 11-y.o Children : Third Phase of a Cohort Study in Franche-Comté
|
N/A | |
| Completed |
NCT06239662 -
Therapeutic Education Groups for Childhood Obesity
|
N/A | |
| Not yet recruiting |
NCT02889406 -
Motivation Approach for Childhood Obesity Treatment
|
N/A | |
| Withdrawn |
NCT02767830 -
Cleveland Kids Run
|
N/A | |
| Completed |
NCT03245164 -
The Effects of Group Exercise and Basketball on Obese Children
|
N/A | |
| Completed |
NCT02559076 -
The Eat Right Emirates Healthy Lifestyle Study
|
N/A | |
| Completed |
NCT02484976 -
Brain Activation and Satiety in Children: Functional Magnetic Resonance Imaging
|
N/A | |
| Completed |
NCT02087774 -
Brief Physical Activity Program to Increase Physical Fitness in Elementary School Children
|
N/A | |
| Completed |
NCT01977105 -
Healthy Growth Abbreviated Pilot Study
|
N/A | |
| Completed |
NCT01821313 -
CASH- Children Active to Stay Healthy
|
N/A | |
| Completed |
NCT01789671 -
Peer Counseling in Family-Based Treatment for Childhood Obesity
|
N/A | |
| Completed |
NCT01849315 -
Effects of Physical Activity on Disease Risk Factors
|
N/A | |
| Completed |
NCT02637752 -
Nutrition and Physical Activity Counselling
|
N/A | |
| Completed |
NCT02799433 -
Evaluation of the Healthy Apple Program in San Francisco
|
N/A | |
| Completed |
NCT01246349 -
Motivational Interviewing for Weight Loss
|
N/A |