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Carotid Stenosis clinical trials

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NCT ID: NCT00805311 Terminated - Stroke Clinical Trials

Aggressive Medical Treatment Evaluation for Asymptomatic Carotid Artery Stenosis

AMTEC
Start date: April 2009
Phase: Phase 4
Study type: Interventional

The aim of this study is to determine whether optimal medical treatment can postpone carotid endarterectomy.

NCT ID: NCT00742612 Terminated - Carotid Stenosis Clinical Trials

Effect of ARC1779 on Cerebral Microembolism in Patients Undergoing Carotid Endarterectomy

Start date: February 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine, in patients undergoing carotid endarterectomy, the effect of ARC1779 Injection on the number of microembolic signals detected by transcranial Doppler immediately after surgery. This study will also evaluate the safety of ARC1779 Injection with respect to bleeding risk in patients in the peri-operative (during surgery) period.

NCT ID: NCT00597545 Terminated - Diabetes Clinical Trials

Effect of Raised CBF During CEA on Cognition in DM Patients

Start date: March 2007
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if we can reduce the incidence of cognitive dysfunction — difficulty in performing certain pencil-paper, memory, finger dexterity and thinking type of tasks called neuropsychometric tests — in patients with adult onset diabetes mellitus (DM) undergoing surgery on the carotid artery (CEA). We hypothesize that cognitive dysfunction can be decreased in patients with type II DM by augmenting cerebral blood flow with a shunt during carotid endarterectomy compared to patients with Type II DM who are treated with "conventional" management in which a shunt is placed only if the electroencephalogram (EEG) indicates cerebral ischemia.

NCT ID: NCT00478673 Terminated - Carotid Stenosis Clinical Trials

Post-Approval Study of the NexStent Carotid Stent System and the FilterWire EZ Embolic Protection System: SONOMA

SONOMA
Start date: May 2007
Phase: Phase 4
Study type: Interventional

The primary objective of the SONOMA Registry is to confirm the safety of the NexStent® Carotid Stent System and FilterWire EZ™ Embolic Protection System in routine clinical practice and to identify rare or unanticipated device-related events that might occur.

NCT ID: NCT00395785 Terminated - Carotid Stenosis Clinical Trials

Evaluation of the TriActiv ProGuard System During Carotid Artery Stenting

Start date: November 2006
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of the TriActiv® ProGuard™ System when used during a stent placement in a blockage within the carotid artery in patients considered to be at high risk for complications from surgical endarterectomy.

NCT ID: NCT00335972 Terminated - Clinical trials for Carotid Artery Stenosis

The Effects of Dexmedetomidine and Remifentanil on Carotid Patients

Start date: June 2006
Phase: Phase 4
Study type: Interventional

We propose to test whether intraoperative administration of dexmedetomidine will reduce hemodynamic control in the intra- and post-operative periods and reduces PACU analgesic requirements in patients undergoing carotid endarterectomy.

NCT ID: NCT00228176 Terminated - Obesity Clinical Trials

Atherosclerosis Underlying Development Assessed by Intima-Media Thickness in Patients on Rimonabant (Auditor)

Start date: August 2005
Phase: Phase 3
Study type: Interventional

Objectives: - Primary: To evaluate the effect of rimonabant 20-mg once daily in comparison with placebo, on the quantitative progression of atherosclerosis as assessed by carotid artery intima-media thickness (CIMT) - Secondary: To evaluate the safety and tolerability of the above rimonabant regimen in the study population of atherosclerosis patients.

NCT ID: NCT00126139 Terminated - Stroke Clinical Trials

Abciximab for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic Carotid Stenosis

Start date: April 2004
Phase: Phase 3
Study type: Interventional

The purpose of the present prospective, randomized, double-blind, double dummy controlled multicenter pilot study is to investigate whether abciximab, compared with aspirin, is able to reduce the rate of recurrent ischemic strokes before and during carotid endarterectomy [CEA] (primary endpoints); and the degree of carotid stenosis, number of microembolic signal (MES) counts, number of ischemic infarcts at diffusion weighted imaging (DWI) and amount of intraluminal thrombus at pathological examination (secondary endpoints) in patients with ischemic stroke due to a >50% carotid stenosis who will undergo CEA.

NCT ID: NCT00106938 Terminated - Stroke Clinical Trials

Carotid Angioplasty and Stenting Versus Endarterectomy in Asymptomatic Subjects Who Are at Standard Risk for Carotid Endarterectomy With Significant Extracranial Carotid Stenotic Disease (ACT I)

ACT I
Start date: April 2005
Phase: Phase 3
Study type: Interventional

The study is being conducted to demonstrate the non-inferiority of carotid artery stenting (CAS) using the Emboshield® Embolic Protection System with the Xact® Carotid Stent System to carotid endarterectomy (CEA) for the treatment of asymptomatic extracranial carotid atherosclerotic disease.