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Carotid Stenosis clinical trials

View clinical trials related to Carotid Stenosis.

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NCT ID: NCT03786666 Not yet recruiting - Stroke Clinical Trials

Ultrasound Evaluation of Carotid Artery Atherosclerotic Plaques and Recanalization

Start date: January 1, 2019
Phase:
Study type: Observational

The purpose of this multiple-center study are: 1) To establish the ultrasound criteria for evaluating vulnerable plaques by comparing the plaque echo characteristics before CEA (carotid artery endarterectomy) and plaque specimen after CEA. 2) To establish the carotid artery recanalization strategies based on the evaluation results of carotid artery and intracranial artery by color doppler flow imaging and TCCS/TCD (transcranial color coded sonography/transcranial doppler). 3) To compare the success rate and the incidence of restenosis between CEA and carotid artery stenting.

NCT ID: NCT03764306 Terminated - Stroke, Ischemic Clinical Trials

New Ischemic Cerebral Lesions After Endarterectomy vs. Stenting for the Treatment of Symptomatic Carotid Stenosis

CARECarotid
Start date: May 1, 2015
Phase: N/A
Study type: Interventional

Background and purpose. Even if periprocedural cerebral microembolism associated with carotid endarterectomy or stenting usually does not manifest as clinically overt stroke, neuropsychological disturbances resulting from these events represent an important clinical and socioeconomic problem. Still, it remains unclear whether the use proximal protection can lower the incidence of cerebral embolism associated with the treatment of carotid stenosis. Materials and methods. This was a prospective randomised single-centre study, which was aimed at comparison of surgical eversion endarterectomy with stenting under proximal protection in symptomatic patients. The investigators evaluated the incidence of new ischaemic lesions revealed by the diffusion-weighted magnetic resonance imaging 2-4 days after the treatment and neurologic events.

NCT ID: NCT03757507 Not yet recruiting - Atherosclerosis Clinical Trials

Investigation of Plaque Instability Using Bevacizumab-800CW and MSOT

Carotid
Start date: January 1, 2019
Phase: N/A
Study type: Interventional

Determining whether we could visualize uptake of the fluorescent tracer Bevacizumab-800CW, targeting VEGF-A in atherosclerotic plaques by using the new imaging technique Multispectral Optoacoustic Tomography both in- and ex vivo.

NCT ID: NCT03755362 Not yet recruiting - Clinical trials for Mild Cognitive Impairment

Dental Carotid Cognitive Study

Start date: November 30, 2018
Phase: N/A
Study type: Interventional

Periodontal Disease (PD) is present in 60+% of adults >65 years and is associated with tobacco smoking, diabetes, and atherosclerosis that worsen inflammation, comorbidities common in older people with mild to moderate cognitive impairment (MCI). Older MCI patients are prone to poor oral hygiene and dental health, which if untreated worsens inflammation-mediated brain and nervous system function, and accelerates progression to dementia. Asymptomatic carotid artery stenosis (ACAS) is often a silent disease detected in only ~10% of older adults, and may have a strong association with MCI. This study examines the effects of intensive therapy for periodontitis on cognition in high-risk older people with ACAS. Results could highlight PD as a readily modifiable risk factor for dementia.

NCT ID: NCT03737175 Recruiting - Carotid Stenosis Clinical Trials

Endarterectomy vs Stenting in Chinese Asymptomatic Carotid Stenosis Patients

ESCALATE
Start date: March 30, 2018
Phase: N/A
Study type: Interventional

Endarterectomy vs Stenting Asymptomatic Carotid stenosis patients to verify the efficacy and safety.

NCT ID: NCT03672955 Active, not recruiting - Clinical trials for Internal Carotid Artery Stenosis With Infarction

Advanced Ultrasound Methods in the Assessment of Carotid Plaque Instability

Start date: September 1, 2016
Phase:
Study type: Observational

The primary aim of this project is to assess if advanced ultrasound methods such as SMI (Superb microvascular Imaging) and SWE (Shear Wave Elastography) can identify intraplaque neovascularization and plaque tissue stiffness in carotid artery plaques and relate these results to ipsilateral cerebrovascular symptoms. The secondary aim of this project is to assess the level of agreement between the structural plaque characteristics assessed by advanced ultrasound examinations such as SMI, SWE, CEUS (Contrast enhanced ultrasound), GSM (Plaque gray-scale-median) and carotid MRI, metabolic activity of plaque assessed by 18F-FDG PET/CT with histology as the gold standard. Findings from the methods mentioned above will be related to cerebrovascular symptoms, blood tests (cholesterol-tot, LDL, HDL, CRP, leukocytes, glucose, HbA1c) and other cardiovascular risk factors at inclusion and upon 1 year follow up.

NCT ID: NCT03631381 Recruiting - Carotid Stenosis Clinical Trials

Retrospective Study of Carotid Surgery in Dijon

RESCADI
Start date: September 4, 2017
Phase:
Study type: Observational

The results in carotid surgery are an indicator of the functioning of an academic surgical team, making it possible to evaluate and improve practices, as much among surgeons in training as among senior surgeons. The indications have evolved with the development of symptomatic stenosis surgery, and results analysis has allowed us to improve our practices. It would be of great use to have the statistics obtained in previous years to continue improving our practices.

NCT ID: NCT03596229 Not yet recruiting - Carotid Stenosis Clinical Trials

Major Adverse Cardiac Events After Carotid Endarterectomy

Start date: October 1, 2018
Phase:
Study type: Observational

Carotid endarterectomy is the operation for curing the significant carotid artery stenotic patients who are also at high cardiac risk. This retrospective study is to find out the incidence and risk factors related.

NCT ID: NCT03587324 Completed - Clinical trials for Vascular Surgery Patient With PAD / Carotid Stenosis

Perioperative Aspirin Response in Patients Undergoing Vascular Surgery

Start date: February 2013
Phase: N/A
Study type: Interventional

Reduced antiplatelet activity (low response (LR)/high on-treatment platelet reactivity (HPR)) of aspirin (ALR) or clopidogrel (CLR) is associated with an increased risk of thromboembolic events. The prevalence figures for low-responders reported in the literature vary widely and there have been few investigations in vascular surgery patients to date. The aim of this prospective monocentric study was to increase the evidence base on vascular surgery patients and to detect any changes in the response following vascular surgery procedures.

NCT ID: NCT03516929 Recruiting - Clinical trials for Assessment of Carotid Artery Stenosis and Lower Limb Peripheral Ischemia Prior to Coronary Artery Bypass Surgery

Assessment of Carotid Artery Stenosis and Lower Limb Peripheral Ischemia Prior to CABG

Start date: April 5, 2018
Phase: N/A
Study type: Interventional

From our experience among Egyptian population in our institution, there is an increased prevalence of hidden subclinical peripheral artery disease along with carotid artery affection. Thus, increasing the risk of post-operative morbid complications.We aim to evaluate routine/ non-selective carotid and peripheral arterial screening in asymptomatic patients undergoing coronary artery bypass grafting in the Egyptian populationIt is a prospective, non-randomized, comparative study including two groups of patients. The study will start from the day of approval of the ethical committee. It will include 260 patients, on basis of "all new comers". Patients will be examined and classified as "high-risk" group (ɳ = 130) or "low-risk" group (ɳ=130). All patients will have the "routine" preoperative investigations along with evaluation of extracranial carotid system by non-invasive carotid duplex and lower limb arterial system by non-invasive bilateral lower limb arterial duplex.