Cardiovascular Diseases Clinical Trial
To investigate how inflammation, hemostasis, and stress may contribute to neighborhood and individual-level socioeconomic differences in cardiovascular risk.
BACKGROUND:
In epidemiologic studies, associations of cardiovascular risk with individual and
neighborhood socioeconomic characteristics tend to persist after adjustment for established
cardiovascular risk factors suggesting that other mediators may be involved. However,
evidence regarding what these mediators may be is largely absent. Elucidating the reasons
for these persistent socioeconomic differences may enhance our ability to reduce these
differentials and will contribute to our understanding of the causes of cardiovascular
disease generally. Two biological processes, inflammation and hemostasis, have recently
emerged as potentially important in the development of atherosclerosis and the precipitation
of clinical cardiovascular events. Both processes have also been recently linked to
psychosocial factors and stress. However, studies investigating social gradients in
inflammation and hemostasis remain rare. In addition, the relation of psychosocial factors
and biological markers of the stress response to inflammation and hemostasis have not been
examined in large population-based studies.
DESIGN NARRATIVE:
The study is ancillary to the ongoing epidemiologic study of atherosclerosis, the
Multi-Ethnic Study of Atherosclerosis (MESA). The project will collect data on stress
hormones and follow- up measures of inflammation and hemostasis which are not part of the
existing MESA protocol on a subsample of the cohort. The study will also collect additional
data on neighborhood sources of stress for the subsample. The new data will be linked to
existing MESA data.
Using newly collected data linked to the MESA, the study will investigate (1) associations
of neighborhood and individual-level socioeconomic indicators with markers of inflammation
and hemostasis; (2) associations of individual-level psychosocial factors and sources of
chronic stress (at the individual and neighborhood level) with inflammatory markers and
hemostasis; and (3) the relationship between biological markers of the stress response (such
as cortisol and adrenaline/noradrenaline) and inflammation and hemostasis). Project aims
will be achieved by linking MESA data to newly-collected data on neighborhood
characteristics and biomarkers of inflammation, hemostasis and the stress response in MESA
participants. The project is innovative in that it will span and link three levels: the
social/environmental level (neighborhood characteristics and social position), the
behavioral/psychological level (behavioral and psychosocial factors), and the biological
level (inflammation, hemostasis, and stress hormones). The study will provide a unique
opportunity to elucidate the links between socioeconomic factors, stress, inflammation and
hemostasis in a large and diverse population-based sample.
;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05654272 -
Development of CIRC Technologies
|
||
| Recruiting |
NCT05650307 -
CV Imaging of Metabolic Interventions
|
||
| Recruiting |
NCT04515303 -
Digital Intervention Participation in DASH
|
||
| Completed |
NCT04056208 -
Pistachios Blood Sugar Control, Heart and Gut Health
|
Phase 2 | |
| Recruiting |
NCT04417387 -
The Genetics and Vascular Health Check Study (GENVASC) Aims to Help Determine Whether Gathering Genetic Information Can Improve the Prediction of Risk of Coronary Artery Disease (CAD)
|
||
| Not yet recruiting |
NCT06211361 -
Cardiac Rehabilitation Program in Patients With Cardiovascular Disease
|
N/A | |
| Not yet recruiting |
NCT06032572 -
Evaluation of the Safety and Effectiveness of the VRS100 System in PCI (ESSENCE)
|
N/A | |
| Recruiting |
NCT04514445 -
The BRAVE Study- The Identification of Genetic Variants Associated With Bicuspid Aortic Valve Using a Combination of Case-control and Family-based Approaches.
|
||
| Enrolling by invitation |
NCT04253054 -
Chinese Multi-provincial Cohort Study-Beijing Project
|
||
| Completed |
NCT03273972 -
INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers
|
N/A | |
| Completed |
NCT03680638 -
The Effect of Antioxidants on Skin Blood Flow During Local Heating
|
Phase 1 | |
| Recruiting |
NCT04843891 -
Evaluation of PET Probe [64]Cu-Macrin in Cardiovascular Disease, Cancer and Sarcoidosis.
|
Phase 1 | |
| Completed |
NCT04083872 -
Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of Highdose CKD-385 in Healthy Volunteers(Fasting)
|
Phase 1 | |
| Completed |
NCT04083846 -
Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of High-dose CKD-385 in Healthy Volunteers(Fed)
|
Phase 1 | |
| Completed |
NCT03619148 -
The Incidence of Respiratory Symptoms Associated With the Use of HFNO
|
N/A | |
| Completed |
NCT03693365 -
Fluid Responsiveness Tested by the Effective Pulmonary Blood Flow During a Positive End-expiratory Trial
|
||
| Completed |
NCT03466333 -
Postnatal Enalapril to Improve Cardiovascular fUnction Following Preterm Pre-eclampsia
|
Phase 2 | |
| Completed |
NCT04082585 -
Total Health Improvement Program Research Project
|
||
| Completed |
NCT05132998 -
Impact of a Comprehensive Cardiac Rehabilitation Program Framework Among High Cardiovascular Risk Cancer Survivors
|
N/A | |
| Completed |
NCT05067114 -
Solutions for Atrial Fibrillation Edvocacy (SAFE)
|