Cardiovascular Diseases Clinical Trial
To develop statistical methodologies to study genetic and environmental factors in cardiovascular disease, using age at onset data from population-based family studies of disease incidence.
BACKGROUND:
In the study of chronic diseases, both environmental and genetic factors can be influential.
In highly common diseases, such as coronary heart disease, genetic effects may be more
influential in determining the age of onset of the disease than in determining whether or
not one gets the disease. When sufficient information is available, family studies can help
localize possible disease genes on the human chromosome through genetic linkage analysis,
and familial aggregation of disease can help separate the effects of inheritance,
environment and lifestyle on the risk of disease.
DESIGN NARRATIVE:
The study developed: (1) a general strategy for evaluating the fit of parametric dependence
models for familial clustering of ages at disease-onset; (2) a computationally simple method
for genetic linkage analysis of age at onset data; (3) application and illustration of
recently developed additive frailty models for complex familial dependence structures.
Method (1) was applied to a family study of cardiovascular disease and a twin study of
appendectomy. Method (2) was applied to ongoing genetic studies conducted at the University
of California at San Francisco. Method (3) was applied to a family study of coronary heart
disease in Western Australia. Well-documented, user-friendly programs were developed and
made publicly available.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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