Cardiovascular Diseases Clinical Trial
To elucidate dietary factors that elevate risk for cardiovascular disease (CVD) in conjunction with insulin resistance.
BACKGROUND:
Clinical studies indicate that high carbohydrate intake may exacerbate the dyslipidemia
often seen with insulin resistance. Consequently, there is much debate as to the optimal
dietary pattern for individuals with NIDDM to minimize risk for microvascular disease. Data
on this topic from free-living populations are scarce. In addition, associations of dietary
antioxidants with CVD risk have not been evaluated in large community samples of persons
with diabetes.
DESIGN NARRATIVE:
Potential dietary determinants of hyperinsulinemia or of insulin resistance were evaluated,
including high intake of dietary fats and of simple sugars and low alcohol consumption. As a
major focus, dietary factors that may contribute to elevated CVD risk among persons with
existing insulin resistance, including impaired glucose tolerance (IGT) and
non-insulin-dependent diabetes mellitus (NIDDM) were examined. Five datasets from
epidemiologic studies were available to evaluate specific hypotheses for men and women of
Black, Hispanic and non-Hispanic white ethnicity. The unique contributions of each dataset
were as follows. The San Luis Valley Diabetes Study and the San Antonio Heart Study enabled
prospective analyses for large numbers of subjects with IGT or NIDDM; the Mexico City Study
provided a sample with contrasting dietary patterns in a non-white population; the Kaiser
Permanente Women Twins Study allowed for the removal of genetic influences by evaluating
associations within monozygotic twin pairs; and the Insulin Resistance Atherosclerosis Study
(IRAS) provided direct measurement of insulin sensitivity and subclinical atherosclerosis
across the spectrum of glucose tolerance in three ethnic groups.
An understanding of the accuracy of the dietary assessment instruments used in the three
ethnic groups was critical to the interpretation of the findings related to diet and CVD
risk variables. Therefore, a second component of research was also conducted, that being an
evaluation of the comparative validity of the food frequency interview used in the multi-
cultural IRAS population using a series of 24-hour dietary recalls as the standard.
;
N/A
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05650307 -
CV Imaging of Metabolic Interventions
|
||
Recruiting |
NCT05654272 -
Development of CIRC Technologies
|
||
Recruiting |
NCT04515303 -
Digital Intervention Participation in DASH
|
||
Completed |
NCT04056208 -
Pistachios Blood Sugar Control, Heart and Gut Health
|
Phase 2 | |
Recruiting |
NCT04417387 -
The Genetics and Vascular Health Check Study (GENVASC) Aims to Help Determine Whether Gathering Genetic Information Can Improve the Prediction of Risk of Coronary Artery Disease (CAD)
|
||
Not yet recruiting |
NCT06211361 -
Cardiac Rehabilitation Program in Patients With Cardiovascular Disease
|
N/A | |
Not yet recruiting |
NCT06032572 -
Evaluation of the Safety and Effectiveness of the VRS100 System in PCI (ESSENCE)
|
N/A | |
Recruiting |
NCT04514445 -
The BRAVE Study- The Identification of Genetic Variants Associated With Bicuspid Aortic Valve Using a Combination of Case-control and Family-based Approaches.
|
||
Enrolling by invitation |
NCT04253054 -
Chinese Multi-provincial Cohort Study-Beijing Project
|
||
Completed |
NCT03273972 -
INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers
|
N/A | |
Completed |
NCT03680638 -
The Effect of Antioxidants on Skin Blood Flow During Local Heating
|
Phase 1 | |
Recruiting |
NCT04843891 -
Evaluation of PET Probe [64]Cu-Macrin in Cardiovascular Disease, Cancer and Sarcoidosis.
|
Phase 1 | |
Completed |
NCT04083872 -
Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of Highdose CKD-385 in Healthy Volunteers(Fasting)
|
Phase 1 | |
Completed |
NCT04083846 -
Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of High-dose CKD-385 in Healthy Volunteers(Fed)
|
Phase 1 | |
Completed |
NCT03619148 -
The Incidence of Respiratory Symptoms Associated With the Use of HFNO
|
N/A | |
Completed |
NCT03466333 -
Postnatal Enalapril to Improve Cardiovascular fUnction Following Preterm Pre-eclampsia
|
Phase 2 | |
Completed |
NCT03693365 -
Fluid Responsiveness Tested by the Effective Pulmonary Blood Flow During a Positive End-expiratory Trial
|
||
Completed |
NCT04082585 -
Total Health Improvement Program Research Project
|
||
Completed |
NCT05132998 -
Impact of a Comprehensive Cardiac Rehabilitation Program Framework Among High Cardiovascular Risk Cancer Survivors
|
N/A | |
Completed |
NCT05067114 -
Solutions for Atrial Fibrillation Edvocacy (SAFE)
|