Cardiovascular Diseases Clinical Trial
To conduct a comprehensive epidemiologic investigation into the relationship between serum triglyceride (TG) levels and coronary heart disease (CHD).
BACKGROUND:
The results of this investigation helped to shed substantial light on the controversial
relationship between triglycerides and coronary heart disease, a topic of great importance
to preventive cardiology. Additionally, important methodological information was obtained in
the study of interactions and precision of variables in epidemiologic analysis.
DESIGN NARRATIVE:
There were three components to the study: 1) an analysis of several existing cardiovascular
databases for evidence of a significant association between coronary heart disease and
specific lipid interactions involving triglycerides; 2) an analysis of these databases to
investigate the role of measurement precision on the association between elevated
triglyceride levels and coronary heart disease; and 3) a survey of both expert lipidologists
and community clinicians to examine current practices related to screening for and treatment
of elevated triglyceride levels for the purpose of reducing coronary heart disease risk.
Five databases were used in the first two components of this study. These data sets included
those of the Lipid Research Clinics Prevalence and Mortality Follow-up Studies; the Lipid
Research Clinics Coronary Primary Prevention Trial; the Multiple Risk Factor Intervention
Trial; the National Heart, Lung, and Blood Type II Coronary Intervention Study; and the
Coronary Drug Project. For the first component, detailed statistical analyses of all
databases were performed, specifically examining the role of lipid interactions involving
triglycerides and their association with coronary heart disease. For the second component,
more precise estimates of each subject's lipid levels were recalculated using the multiple
lipid measurements already available in each database. Each dataset was then analyzed for
evidence of an independent relationship between triglycerides and coronary heart disease and
to validate the theoretical findings suggesting that measurement imprecision may explain the
difficulty of detecting an independent triglyceride-coronary heart disease association. The
public health implications of the current state of knowledge surrounding triglycerides were
assessed with survey research techniques in the third component.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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