Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00005155
Other study ID # 1027
Secondary ID R01HL028094
Status Completed
Phase N/A
First received May 25, 2000
Last updated May 12, 2016
Start date February 1982
Est. completion date January 1989

Study information

Verified date May 2000
Source National Heart, Lung, and Blood Institute (NHLBI)
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

To test the physiological and psychosocial correlates of Type A behavior.


Description:

BACKGROUND:

The Type A behavior pattern as described by Friedman and Rosenman is characterized by extremes of competitiveness, easily aroused hostility, a sense of urgency and aggression. In 1981 the Review Panel of Coronary Prone Behavior and Coronary Heart Disease concluded that the Type A behavior pattern was associated with an increased risk for coronary heart disease. Studies have challenged the independent predictive value of the behavior pattern with respect to coronary heart disease. There was a need to develop physiological measurements related to coronary-prone behavior and to reexamine the stability of the psychological assessment. It was hypothesized that Type A behavior or some component such as hostility might be associated with a state of chronic, generalized sympathetic-adrenal arousal. Preliminary research was conducted on interpersonal dynamic correlates of Type A behavior among married couples. Research was needed on whether certain types of marriages, according to the Type A/B classification of the two spouses, are more pathogenic than others. Additional research is also needed on which components of the global Type A pattern were of primary importance as risk factors for coronary disease, and which components were enduring, which were transient, and which were situationally related.

In 1982, a household survey on Type A behavior was initiated. Measures included the Jenkins Activity Survey, the Framingham Type A Questionnaire, hostility scales, and other behavioral tests. Information was also collected on demographic variables, social support, marital satisfaction, life events, social values, and job and family stress. After the household survey was completed, the respondents were contacted by the Type A interviewers and the Structured Interviews conducted. A total of 1,114 Type A interviews were completed yielding 902 primary respondents and 239 spouses.

DESIGN NARRATIVE:

The concurrent relationship of the Structured Interview (SI) global and component Type A behavior measures were tested to levels of chronic and acute sympathetic nervous system activity, as assessed by platelet and plasma catecholamines, heart rate, blood pressure, and pupil size. The correlations among heart rate, pupil size, blood pressure, and the plasma and platelet catecholamine measures were determined as were the relationships with reported global health, chronic disease, and functional disability levels. The five-year predictability was tested of reported global health, chronic disease, and functional disability from measures of global and component Type A behavior.

Tests were made of the differences in the chronic and acute sympathetic-adrenal responses, as assessed by platelet and plasma catecholamines, pupil size, heart rate, and blood pressure, among married couples having different combinations of Structured Interview global and component Type A classifications. The five year marital stability and health of these couples were followed. A comparison was made of one week test-retest reliability with the five year stability of the Structured Interview global and component Type A measures.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.


Recruitment information / eligibility

Status Completed
Enrollment 0
Est. completion date January 1989
Est. primary completion date
Accepts healthy volunteers No
Gender Male
Age group N/A to 100 Years
Eligibility No eligibility criteria

Study Design

N/A


Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
National Heart, Lung, and Blood Institute (NHLBI)

References & Publications (4)

Cwikel JM, Dielman TE, Kirscht JP, Israel BA. Mechanisms of psychosocial effects on health: the role of social integration, coping style and health behavior. Health Educ Q. 1988 Summer;15(2):151-73. — View Citation

Dielman TE, Butchart AT, Moss GE, Harrison RV, Harlan WR, Horvath WJ. Psychometric properties of component and global measures of structured interview assessed type A behavior in a population sample. Psychosom Med. 1987 Sep-Oct;49(5):458-69. — View Citation

Harlan WR: Rationale for Intervention on Blood Pressure in Childhood and Adolescence. In: Matarazzo JD, Weiss SM, Herd JA, (Eds), Behavioral Health: A Handbook of Health Enhancement and Disease Prevention. New York: Wiley & Sons, 1984

Moss GE, Dielman TE, Campanelli PC, Leech SL, Harlan WR, Harrison RV, Horvath WJ. Demographic correlates of SI assessments of type A behavior. Psychosom Med. 1986 Nov-Dec;48(8):564-74. — View Citation

See also
  Status Clinical Trial Phase
Recruiting NCT05654272 - Development of CIRC Technologies
Recruiting NCT05650307 - CV Imaging of Metabolic Interventions
Recruiting NCT04515303 - Digital Intervention Participation in DASH
Completed NCT04056208 - Pistachios Blood Sugar Control, Heart and Gut Health Phase 2
Recruiting NCT04417387 - The Genetics and Vascular Health Check Study (GENVASC) Aims to Help Determine Whether Gathering Genetic Information Can Improve the Prediction of Risk of Coronary Artery Disease (CAD)
Not yet recruiting NCT06211361 - Cardiac Rehabilitation Program in Patients With Cardiovascular Disease N/A
Not yet recruiting NCT06032572 - Evaluation of the Safety and Effectiveness of the VRS100 System in PCI (ESSENCE) N/A
Recruiting NCT04514445 - The BRAVE Study- The Identification of Genetic Variants Associated With Bicuspid Aortic Valve Using a Combination of Case-control and Family-based Approaches.
Enrolling by invitation NCT04253054 - Chinese Multi-provincial Cohort Study-Beijing Project
Completed NCT03273972 - INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers N/A
Completed NCT03680638 - The Effect of Antioxidants on Skin Blood Flow During Local Heating Phase 1
Recruiting NCT04843891 - Evaluation of PET Probe [64]Cu-Macrin in Cardiovascular Disease, Cancer and Sarcoidosis. Phase 1
Completed NCT04083846 - Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of High-dose CKD-385 in Healthy Volunteers(Fed) Phase 1
Completed NCT04083872 - Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of Highdose CKD-385 in Healthy Volunteers(Fasting) Phase 1
Completed NCT03693365 - Fluid Responsiveness Tested by the Effective Pulmonary Blood Flow During a Positive End-expiratory Trial
Completed NCT03466333 - Postnatal Enalapril to Improve Cardiovascular fUnction Following Preterm Pre-eclampsia Phase 2
Completed NCT03619148 - The Incidence of Respiratory Symptoms Associated With the Use of HFNO N/A
Completed NCT04082585 - Total Health Improvement Program Research Project
Completed NCT05132998 - Impact of a Comprehensive Cardiac Rehabilitation Program Framework Among High Cardiovascular Risk Cancer Survivors N/A
Completed NCT05067114 - Solutions for Atrial Fibrillation Edvocacy (SAFE)