Cardiovascular Diseases Clinical Trial
Official title:
HDL-Cholesterol is Inversely Related With Inflammation in Cardiac Syndrome X
High density lipoprotein cholesterol (HDL-C) is in the centrum of the process of reverse
cholesterol transport from peripheral cells to the liver[10]. HDL-C promotes endothelial
generation of nitric oxide (NO) and improves endothelial function and arterial
vasoreactivity[11]. In several studies, lower HDL-C level was reported to be associated with
increased coronary artery disease (CAD) risk[12-14]. HDL-C also has anti- inflammatory and
anti-oxidant activities[15,16]. Concerning anti-inflammatory activity, HDL-C inhibits the
activation of monocytes/macrophages and neutrophils[17,18] and inhibits the expression of
endothelial adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and
E-selectin[15].
In this study we aimed to investigate the relation of HDL-C level with systemic inflammatory
markers in patients with cardiac syndrome X (CSX).
n/a
Observational Model: Case-Crossover, Time Perspective: Retrospective
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