Cardiovascular Diseases Clinical Trial
Official title:
Effect of Growth Hormone Replacement Therapy on Cardiovascular Risk Factors in Adult Patients With Severe Growth Hormone Deficiency: Association With IGF-I Concentration
Rationale: Abnormally low and high levels of insulin-like growth factor-I (IGF-I) are both
associated with increased metabolic risk. Since (U-shaped) associations of IGF-I, within the
normal range, have also been found with cardiovascular risk factors and disease in the
general population, it would be interesting to investigate if this association can also be
found in growth hormone deficient (GHD) adults treated with Growth Hormone (GH). This could
be of interest for endocrinologists prescribing GH in clinical practice because strict
dosing may become even more important. Next to that, scientific evidence for clinical
practice is wanted.
Objective: Next to cardiovascular risk factors (main objectives: body composition and lipid
profile; secondary objectives: remainder) we investigate the effect on glucose metabolism,
physical performance, and neuropsychological functioning of different levels of IGF-I in GH
treated GHD men and women.
Study design: Open-label randomized trial.
Study population: At least 32 subjects, both childhood as adult onset GHD men and women,
receiving GH treatment for at least one year, with an age between 20 and 65 years.
Intervention: At entry subjects are already receiving GH treatment according to general
clinical practice, and are expected to demonstrate an IGF-I concentration of 0 - 1 SD score
(SDS) (normal dose). The group of men and group of women will be randomized to receive
either a decrease of their regular dose of GH treatment (IGF-I target level of -2 - -1 SDS)
(low dose), or an increase of their regular dose, (IGF-I target level of 1 - 2 SDS) (high
dose) for at least 24 weeks.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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