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Preoperative Infusion of Levosimendan in Patients Undergoing Cardiac Surgery

Cardiac Surgery Clinical Trial

Official title:
Preoperative Infusion of Levosimendan in High Risk Cardiac Surgery Patients: A Retrospective Study

Clinical Trial Summary

The aim of this retrospective study will be to investigate the effect of the preoperative administration of levosimendan on the outcome of patients with compromised cardiac function undergoing cardiac surgery

Clinical Trial Description

Patients with severely reduced left ventricular ejection fraction (LVEF) face a high risk of morbidity and mortality after cardiac surgery. Impaired cardiac function preoperatively predisposes patients to low cardiac output syndrome. Levosimendan acts by a different mechanism than traditional inotropes and its preoperative use could improve the outcome of patients with cardiac failure. Specifically, it promotes vasodilation of coronary, pulmonary and systemic vessels, has an anti-inflammatory and anti-oxidant effect and enhances cardiac contractility by improving the response of the myofilaments to intracellular calcium. The aim of this retrospective study will be to investigate the effect of the preoperative administration of levosimendan on the outcome of patients with compromised cardiac function undergoing cardiac surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04635293
Study type Interventional
Source Aretaieion University Hospital
Contact
Status Completed
Phase N/A
Start date January 1, 2012
Completion date November 9, 2020
View Details
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