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NCT ID: NCT05303844 Recruiting - Clinical trials for Refractory Malignant Ascites

Oncolytic Virotherapy Plus PD-1 Inhibitor for Patients With Refractory Malignant Ascites

Start date: April 2, 2022
Phase: Phase 1
Study type: Interventional

The objective of this study is to evaluate the safety/tolerability efficacy of oncolytic virotherapy combined with Tislelizumab for patients with refractory malignant ascites.

NCT ID: NCT05306782 Recruiting - Stuttering Clinical Trials

Shaping Motor Neural Functioning of Developmental Stuttering to Improve Fluency

Start date: April 2, 2022
Phase: N/A
Study type: Interventional

Developmental stuttering (DS) is a motor/speech disorder, characterized by specific alterations in the functioning of brain circuits. Non-invasive brain stimulation may be useful to shape the altered functioning and connectivity of these systems. As a consequence, this project aims to expand the neurophysiological understanding of DS, evaluating effects of transcranial electrical stimulation (tES) on speech fluency and brain functioning of adults with persistent DS. This project will provide high-impact insights into the functioning of DS neural system, also proposing innovative and/or personalized rehabilitation.

NCT ID: NCT05320679 Recruiting - Low Back Pain Clinical Trials

Development of Pain Related Avoidance of Movement Questionnaire

Start date: April 2, 2022
Phase:
Study type: Observational

In recent studies, it has been shown that people may have avoidance of movement due to pain. However, there is no scale that evaluates avoidance of movement due to pain in musculoskeletal problems. The aim of this study is to develop a scale to measure how much pain-related movement and activity is avoided in individuals with musculoskeletal pain, and to examine the results of its clinical application.

NCT ID: NCT05325021 Recruiting - Refractive Errors Clinical Trials

Correction of Anisometropic Amblyopia in Children.

Start date: April 2, 2022
Phase:
Study type: Observational

Anisometropic amblyopia among children in school age may affects quality of life and educational progress of children.

NCT ID: NCT05375786 Recruiting - COVID-19 Clinical Trials

Epidemiological Study on Asymptomatic Infections and Mild Illness With Covid-19 in Shanghai

Start date: April 2, 2022
Phase:
Study type: Observational

this study is to clarify the epidemiological characteristics of Omicron variant infected persons in Shanghai, such as distribution characteristics, host and clinical characteristics, disease outcome and risk factors. especially asymptomatic infections.

NCT ID: NCT05853224 Recruiting - Dermal Filler Clinical Trials

An Interventional Study to Evaluate the Safety and Performance of Crosslinked Hyaluronic Acid Hydrogel

Start date: April 2, 2022
Phase: N/A
Study type: Interventional

The aim of this interventional, pre-market, double- blinded, controlled, two stages study is to evaluate the performance and safety of Crosslinked Hyaluronic Acid (CLHA) Hydrogel (with and without Lidocaine) for the Treatment of Soft Tissue Deficits.

NCT ID: NCT05890521 Recruiting - COVID-19 Clinical Trials

Safety Study of COVID19 Vaccine on the Market

Start date: April 2, 2022
Phase: Phase 4
Study type: Interventional

Popular topic:Multi-center safety observation of recombinant Novel Coronavirus protein vaccine (CHO cells) in a large population Study population:People aged 18 and above

NCT ID: NCT06239623 Recruiting - Melanoma Clinical Trials

ERK Inhibitor JSI-1187 in Advanced Solid Tumors

Start date: April 2, 2022
Phase: Phase 1
Study type: Interventional

JSI-1187-101 phase 1 study

NCT ID: NCT04927676 Recruiting - AMH Clinical Trials

Hormones in Hypogonadotropic Hypogonadism

Start date: April 2, 2023
Phase:
Study type: Observational

Therefore, the main objective of this prospective pilot study is to evaluate a complete hormonal profile in women with hypogonadotropic hypogonadism, including anti-mullerian hormone (AMH) and antral follicle count. Changes in this regard will be evaluated after 2 months of individual treatment.

NCT ID: NCT05562310 Recruiting - Stable Neonates Clinical Trials

Phenylalanine, Methionine and Histidine Requirements in TPN Fed Neonates

Start date: April 2, 2023
Phase: N/A
Study type: Interventional

This is a single center project assessing the requirements for three essential amino acids in TPN fed neonates. Using the Carbon Oxidation method (indicator amino oxidation and direct amino acid oxidation method), the investigators will determine the requirement of each of the 3 amino acids. The investigators will first determine the requirement for Phenylalanine, then Methionine and finally Histidine. The investigators will recruit 18 - 20 babies per amino acid study. Breath and urine samples will be collected to determine the oxidation of the indicator amino acid. The response of the indicator amino acid to changes in intake of the test amino acid (phenylalanine, methionine, and histidine) will be analyzed by bi-phase linear mixed effect model to determine the breakpoint or mean requirement for each amino acid. It is hypothesized that the requirement for phenylalanine, methionine and histidine will be at least 50% lower than what is currently available in commercial amino acids solutions used for TPN feeding of neonates.