Breast Cancer Clinical Trial
Official title:
A Study of the Docetaxel Pharmacodynamics and Polymorphisms in ABCC2 and SLC01B3 in Caucasian and African-American Cancer Patients
This research trial studies deoxyribonucleic acid (DNA) in blood samples from Caucasian and African-American cancer patients who received docetaxel on clinical trial CLB-9871. Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about how docetaxel is used by the body.
PRIMARY OBJECTIVES:
I. To determine the genotype of ATP-binding cassette, sub-family C (CFTR/MRP), member 2
(ABCC2) and solute carrier organic anion transporter family, member 1B3 (SLCO1B3) (and other
genes potentially relevant in the pharmacokinetics and pharmacodynamics of docetaxel in the
future) in Caucasian and African-American cancer patients enrolled on clinical trial
CLB-9871.
II. Explore the relationships between these genotypes and docetaxel pharmacokinetic
parameters (e.g., area under curve [AUC], steady-state volume of distribution [Vdss]).
OUTLINE:
Blood samples collected on clinical trial CLB-9871 are examined via ABCC2 and SLC01B3
genotyping using TaqMan analysis. Other genes related to the pharmacokinetics and side
effects of docetaxel may be considered for future genotyping. In some cases, panels of drug
response single nucleotide polymorphisms (SNPs) on high-density arrays may be genotyped.
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