Breast Cancer Clinical Trial
Official title:
A Phase 2 Multicenter Study Evaluating the Efficacy and Safety of IPI-504 in Combination With Trastuzumab in Patients With Pretreated, Locally Advanced or Metastatic Human Epidermal Growth Factor Receptor 2 (HER2) Positive Breast Cancer
The purpose of this study is to see if IPI-504 in combination with trastuzamab is an effective treatment in HER2 positive metastatic breast cancer
Recent clinical data has demonstrated that even in heavily pretreated patients with
trastuzumab-refractory HER-2 positive breast cancer, targeting HER2 is efficacious.
IPI-504 is an HSP90 inhibitor and is chemically related to 17-AAG and it has been studied in
a clinical trial in combination with trastuzamab and a response rate of 26% (7/27) was
demonstrated in patients with pretreated, HER2-positive breast cancer. These data provide a
strong scientific rationale for clinical testing of IPI-504 plus trastuzumab in patients
with pretreated, locally advanced or metastatic HER2-positive breast cancer
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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