Breast Cancer Clinical Trial
Official title:
Pharmacokinetics of Weekly Docetaxel in Patients Age 65 and Older With Metastatic Breast or Lung Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, use different ways to stop tumor
cells from dividing so they stop growing or die.
PURPOSE: This phase II trial is studying how well docetaxel works in treating older patients
with metastatic breast, lung, or prostate cancer.
OBJECTIVES:
- Determine the pharmacokinetics of docetaxel in older patients with metastatic breast,
lung, or prostate cancer.
- Determine the response of patients treated with this drug.
- Determine the toxicity of this drug in these patients.
- Determine the short-term changes in functional status, in terms of activities of daily
living, independent activities of daily living, and Karnofsky performance status, in
patients treated with this drug.
- Correlate the number of comorbid conditions at baseline with declines in functional
status in patients treated with this drug.
OUTLINE: Patients receive docetaxel IV over 30 minutes once weekly for 3 weeks. Courses
repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study within 1 year.
;
Masking: Open Label, Primary Purpose: Treatment
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