Breast Cancer Clinical Trial
Official title:
Is Lipid Composition Mapping Using Magnetic Resonance Imaging an Effective Early Detection Tool for Breast Cancer in High Risk Populations?
NCT number | NCT03949946 |
Other study ID # | 2-025-19 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | June 20, 2019 |
Est. completion date | December 31, 2021 |
This study aims to investigate if lipid composition mapping using magnetic resonance imaging could improve early and accurate cancer detection in genetic mutation carriers at high risk of breast cancer. It is hypothesised that there is a significant difference in the extent of spatial variation in lipid composition in breast from MRI between genetic mutation carriers and patients with breast cancer.
Status | Recruiting |
Enrollment | 40 |
Est. completion date | December 31, 2021 |
Est. primary completion date | November 30, 2021 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - female over 18 years old - BRCA1/2 or TP53 gene carriers (high-risk group) - invasive ductal carcinoma of the breast (patient group) - not having any metabolic disorders (e.g., diabetes) - not on any long term medications that may affect lipid metabolism (e.g., statins) Exclusion Criteria: - female under 18 years old - male - affected by metabolic disorders (e.g., diabetes) - on long term medications that affect lipid metabolism (e.g., statins) - contraindicated for MR investigations (poor renal function and metal implants) - concurrent cancer in other sites - concurrent hormone treatment, chemotherapy or underwent surgery - non-English speakers |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Aberdeen Biomedical Imaging Centre | Aberdeen | Aberdeenshire |
Lead Sponsor | Collaborator |
---|---|
University of Aberdeen | NHS Grampian |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Saturated fatty acids in breasts of patients and high-risk group | Saturated fatty acids (SFA) from tumour border and fatty tissue in patients and fibroglandular and fatty tissue in high-risk group SFA will be measured in percentage (%) |
Baseline | |
Primary | Monounsaturated fatty acids in breasts of patients and high-risk group | Monounsaturated fatty acids (MUFA) from tumour border and fatty tissue in patients and fibroglandular and fatty tissue in high-risk group MUFA will be measured in percentage (%) |
Baseline | |
Primary | Polyunsaturated fatty acids in breasts of patients and high-risk group | Polyunsaturated fatty acids (PUFA) from tumour border and fatty tissue in patients and fibroglandular and fatty tissue in high-risk group PUFA will be measured in percentage (%) |
Baseline |
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