Breast Cancer Clinical Trial
Official title:
A Phase II Randomized Clinical Trial Evaluating Neoadjuvant Therapy Regimens With Weekly Paclitaxel Plus Neratinib or Trastuzumab or Neratinib and Trastuzumab Followed by Doxorubicin and Cyclophosphamide With Postoperative Trastuzumab in Women With Locally Advanced HER2-Positive Breast Cancer
Verified date | October 2021 |
Source | NSABP Foundation Inc |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
FB-7 is a Phase II, multi-center randomized study of neratinib in combination with weekly paclitaxel with or without trastuzumab followed by doxorubicin and cyclophosphamide (AC) as neoadjuvant therapy for women with HER2-positive locally advanced breast cancer. Patients in the control arm will receive neoadjuvant trastuzumab in combination with weekly paclitaxel followed by AC. The primary aim of the study is to determine the pathologic complete response (pCR) rate in breast and axillary nodes following the neoadjuvant therapy regimens. The secondary aims include determination of the pCR rate in breast only, clinical complete response (cCR) rate, two-year recurrence-free interval, two-year overall survival, toxicity of the neoadjuvant regimens, and exploration of molecular and genetic correlates of response.
Status | Completed |
Enrollment | 141 |
Est. completion date | November 25, 2016 |
Est. primary completion date | September 2015 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patients should have a life expectancy of at least 10 years, excluding their diagnosis of breast cancer. - Submission of a block from the diagnostic biopsy sample and from the surgical sample, if gross residual disease greater than or equal to 1.0 cm was removed at the time of surgery, is required for all patients - Patients of reproductive potential must agree to use an effective non-hormonal method of contraception during therapy and for at least 6 months after the last dose of study therapy. - The Eastern Cooperative Oncology Group (ECOG) performance status must be 0 or 1. - Patients must have the ability to swallow oral medication. - The diagnosis of invasive adenocarcinoma of the breast must have been made by core needle biopsy or by limited incisional biopsy. - Patients must have ER analysis performed on the primary tumor prior to randomization. If ER analysis is negative, then progesterone receptor (PgR) analysis must also be performed. (Patients are eligible with either hormone receptor-positive or hormone receptor-negative tumors.) - Breast cancer must be determined to be HER2-positive prior to randomization. Assays using FISH or CISH require gene amplification. Assays using IHC require a strongly positive (3+) staining score. - Clinical staging, based on the assessment by physical exam, must be American Joint Committee on Cancer (AJCC) stage IIB, IIIA, IIIB, or IIIC: cT2 and cN1; cT3 and cN0 or cN1; Any cT and cN2 or cN3; or cT4 - The patient must have a mass in the breast or axilla measuring greater than or equal to 2.0 cm by physical exam, unless the patient has inflammatory breast cancer, in which case measurable disease by physical exam is not required. - At the time of randomization, blood counts performed within 4 weeks prior to randomization must meet the following criteria: absolute neutrophil count (ANC) must be greater than or equal to 1200/mm3; Platelet count must be greater than or equal to 100,000/mm3; Hemoglobin must be greater than or equal to 10 g/dL - The following criteria for evidence of adequate hepatic function performed within 4 weeks prior to randomization must be met: total bilirubin must be less than or equal to upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation greater than ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin; and alkaline phosphatase must be less than or equal to 2.5 x ULN for the lab; and aspartate aminotransferase (AST) and ALT must be less than or equal to 1.5 x ULN for the lab. - Patients with alkaline phosphatase greater than ULN but less than or equal to 2.5 x ULN are eligible for inclusion in the study if liver imaging (CT, MRI, PET, or PET-CT scan) performed within 4 weeks prior to randomization does not demonstrate metastatic disease and the requirements for adequate hepatic function are met. - Patients with either unexplained skeletal pain or alkaline phosphatase that is greater than ULN but less than or equal to 2.5 x ULN are eligible for inclusion in the study if a bone scan, PET-CT scan, or PET scan performed within 4 weeks prior to randomization does not demonstrate metastatic disease. Patients with suspicious findings on bone scan or PET scan are eligible if suspicious findings are determined to be benign by x-ray, MRI, or biopsy. - Serum creatinine performed within 4 weeks prior to randomization must be less than or equal to 1.5 x ULN for the lab. - The left ventricular ejection fraction (LVEF) assessment by 2-D echocardiogram or multiple gated acquisition(MUGA) scan performed within 90 days prior to randomization must be greater than or equal to 50% regardless of the facility's LLN. Exclusion Criteria: - fine-needle aspiration (FNA) alone to diagnose the primary breast cancer. - Excisional biopsy or lumpectomy performed prior to randomization. - Surgical axillary staging procedure prior to randomization. (Procedures that are permitted prior to study entry include: 1) FNA or core biopsy of an axillary node for any patient, and 2) although not recommended, a pre-neoadjuvant therapy SN biopsy for patients with clinically negative axillary nodes.) - Definitive clinical or radiologic evidence of metastatic disease. (Note: Chest imaging [mandatory for all patients] and other imaging [if required] must have been performed within 90 days prior to randomization.) - History of ipsilateral invasive breast cancer regardless of treatment or ipsilateral ductal carcinoma in situ (DCIS) treated with radiation therapy (RT). (Patients with a history of LCIS are eligible.) - Contralateral invasive breast cancer at any time. (Patients with contralateral DCIS or lobular carcinoma in situ (LCIS) are eligible.) - History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization. - Known metastatic disease from any malignancy (solid tumor or hematologic). - Previous therapy with anthracyclines, taxanes, cyclophosphamide, trastuzumab, or neratinib for any malignancy. - Treatment including RT, chemotherapy, and/or targeted therapy, administered for the currently diagnosed breast cancer prior to randomization. - Continued endocrine therapy such as raloxifene or tamoxifen (or other SERM) or an aromatase inhibitor. (Patients are eligible if these medications are discontinued prior to randomization.) - Any continued sex hormonal therapy, e.g., birth control pills and ovarian hormone replacement therapy. Patients are eligible if these medications are discontinued prior to randomization. - Active hepatitis B or hepatitis C with abnormal liver function tests. - Intrinsic lung disease resulting in dyspnea. - Active infection or chronic infection requiring chronic suppressive antibiotics. - Malabsorption syndrome, ulcerative colitis, inflammatory bowel disease, resection of the stomach or small bowel, or other disease or condition significantly affecting gastrointestinal function. - Persistent greater than or equal to grade 2 diarrhea regardless of etiology. - Sensory or motor neuropathy greater than or equal to grade 2, as defined by the NCI Common Toxicity Criteria for Adverse Effects (CTCAE) v3.0. - Conditions that would prohibit intermittent administration of corticosteroids for paclitaxel premedication. - Chronic daily treatment with corticosteroids with a dose of greater than or equal to 10 mg/day methylprednisolone equivalent (excluding inhaled steroids). - Uncontrolled hypertension defined as a systolic BP greater than 150 mmHg or diastolic BP greater than 90 mmHg, with or without anti-hypertensive medications. (Patients with hypertension that is well-controlled on medication are eligible.) - Cardiac disease (history of and/or active disease) that would preclude the use of any of the drugs included in the treatment regimen. This includes but is not confined to: Active cardiac disease: symptomatic angina pectoris within the past 180 days that required the initiation of or increase in anti-anginal medication or other intervention; ventricular arrhythmias except for benign premature ventricular contractions; supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication; conduction abnormality requiring a pacemaker; valvular disease with documented compromise in cardiac function; and symptomatic pericarditis. History of cardiac disease: myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of LV function; history of documented congestive heart failure (CHF); and documented cardiomyopathy. - Other nonmalignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up. - Pregnancy or lactation at the time of randomization. - The investigator should assess the patient to determine if she has any psychiatric or addictive disorder or other condition that, in the opinion of the investigator, would preclude her from meeting the study requirements. - Use of any investigational agent within 4 weeks prior to randomization. |
Country | Name | City | State |
---|---|---|---|
Canada | Jewish General Hospital | Montreal | Quebec |
Canada | Montreal General Hospital | Montreal | Quebec |
Canada | University of Montreal Hospital Group | Montreal | Quebec |
Italy | Azienda Ospedaliera Fatebenefratelli Milano | Milano | |
Puerto Rico | MBCCOP - San Juan | San Juan | |
Spain | Galicia Hospital Universitario A Coruña | A Coruna | Galicia |
Spain | Cataluna Hospital del Mar | Barcelona | |
Spain | Cataluna Hospital Quiron de Barcelona | Barcelona | |
Spain | Extremadura Hospital San Pedro Alcantara | Caceres | |
Spain | Cataluna Hospital Amau de Vilanova de Lleida | Lleida | |
Spain | Madrid Quiron Madrid | Pozuelo de Alarcon | Madrid |
Spain | Valencia Institut Valencia de Oncologia | Valencia | |
United States | St. Luke's Mountain States Tumor Institute - Boise | Boise | Idaho |
United States | Roper Hosp & Med Asso (Care Alliance Health) | Charleston | South Carolina |
United States | CCOP Carolinas HealthCare System | Charlotte | North Carolina |
United States | Case Western Reserve University/University Hospitals of Cleveland | Cleveland | Ohio |
United States | University of Missouri-Ellis Fischel | Columbia | Missouri |
United States | CCOP - Dayton | Dayton | Ohio |
United States | CCOP - Colorado Cancer Research Program, Inc. | Denver | Colorado |
United States | Hartford Hospital | Hartford | Connecticut |
United States | MD Anderson Cancer Center | Houston | Texas |
United States | St. Vincent Hospital and Health Care Center | Indianapolis | Indiana |
United States | Baptist Cancer Institute - Jacksonville | Jacksonville | Florida |
United States | CCOP - Dayton | Kettering | Ohio |
United States | University of Kentucky Medical Center | Lexington | Kentucky |
United States | Loma Linda University Medical Center | Loma Linda | California |
United States | West Virginia University Hospitals Inc. | Morgantown | West Virginia |
United States | Edward Cancer Center | Naperville | Illinois |
United States | Cancer Institute of New Jersey | New Brunswick | New Jersey |
United States | Allegheny Cancer Center at Allegheny General Hospital | Pittsburgh | Pennsylvania |
United States | NSABP Foundation, Inc. | Pittsburgh | Pennsylvania |
United States | University of Pittsburgh | Pittsburgh | Pennsylvania |
United States | Edward Cancer Center Plainfield | Plainfield | Illinois |
United States | Kootenai Cancer Center | Post Falls | Idaho |
United States | Virginia Commonwealth University Massey Cancer Center | Richmond | Virginia |
United States | CCOP - Metro-Minnesota | Saint Louis Park | Minnesota |
United States | Kaiser Permanente-San Diego | San Diego | California |
United States | Spartanburg Regional Healthcare System | Spartanburg | South Carolina |
United States | University Hospital and Medical Center - SUNY Stony Brook | Stony Brook | New York |
United States | Wake Forest University School of Medicine | Winston-Salem | North Carolina |
United States | York Hospital | York | Pennsylvania |
United States | Yorkville Family Practice | Yorkville | Illinois |
Lead Sponsor | Collaborator |
---|---|
NSABP Foundation Inc | Puma Biotechnology, Inc. |
United States, Canada, Italy, Puerto Rico, Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Pathologic Complete Response in Breast and Axillary Lymph Nodes. | Number of participants with no histologic evidence of invasive tumor cells in the surgical breast specimen, axillary nodes after neoadjuvant chemotherapy | At time of surgery, approximately 7 months | |
Secondary | Pathologic Complete Response in Breast. | Number of participants with by no histologic evidence of invasive tumor cells in the surgical breast specimen. | At time of surgery, approximately 7 months | |
Secondary | Clinical Complete Response, as Measured by Physical Exam | Upon physical exam the number of participants with resolution of all target and non-target lesions identified at baseline and no new lesions or other signs of disease progression. | At the completion of AC prior to surgery, approximately 7 months | |
Secondary | Recurrence-free Interval (RFI) | Number of participants with no events of inoperable progressive disease and local, regional and distant recurrence. | 2 years | |
Secondary | Overall Survival | Number of participants alive at 24 months. | 24 months | |
Secondary | Adverse Events Experienced by Participants as a Measure of Toxicity | Number of patients with at least one adverse event. | Assessed through 2 years from randomization |
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