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NCT ID: NCT06374758 Recruiting - HIV Infections Clinical Trials

Accelerated ART Initiation for PWHIV Who Are Out of Care

ACCELERATE
Start date: April 29, 2024
Phase: Phase 4
Study type: Interventional

The main purpose of the study is to evaluate the effectiveness, of the ACCELERATE model of care to achieve HIV viral suppression at Week 24. The study will also assess the acceptability, appropriateness, feasibility, and sustainability of the ACCELERATE model of care. The ACCELERATE model combines a standardized method for outreach, the use of telehealth for rapid access to an HIV care provider, a simplified pre-approved HIV regimen, a free 30-day medication starter supply, and re-linkage to medical care.

NCT ID: NCT06176859 Recruiting - HIV Clinical Trials

Delivery Optimization for Pre-Exposure Prophylaxis (DO PrEP) Study

Start date: July 17, 2023
Phase: N/A
Study type: Interventional

The overall goal is to determine whether an end-to-end decentralized delivery service for PrEP is more effective, safe, acceptable, and cost-effective than facility-based PrEP delivery.

NCT ID: NCT05962775 Recruiting - Infertility Clinical Trials

Ethanol Sclerotherapy Prior to ART

START
Start date: May 1, 2023
Phase: N/A
Study type: Interventional

The goal of this randomized controlled trial is to assess the impact of ethanol sclerotherapy on ART cycle outcomes. The main questions it aims to answer are: 1. Does ethanol sclerotherapy before ART cycle has any impact on cumulative live birth rate in patients with endometrioma? 2. Does ethanol sclerotherapy improve chronic pelvic pain, dysmenorrhea, complications during oocyte retrieval, response to ovarian stimulation (number of mature oocytes retrieved), and pregnancy loss rates? Infertile patients with endometrioma between 4-10 cm who are scheduled for ART within 2 cycles will be randomized to ethanol sclerotherapy or no intervention.

NCT ID: NCT05625724 Recruiting - Pre-Eclampsia Clinical Trials

Aspirin for the Prevention of Preeclampsia and Pregnancy Outcomes After Assisted Reproductive Technology

APPART
Start date: August 2, 2023
Phase: Phase 3
Study type: Interventional

This study seeks to validate the hypothesis that nulliparous pregnant women after Assisted Reproductive Technology (ART) are at high risk of preeclampsia and perinatal complications and represent a subgroup for which aspirin prophylaxis during pregnancy may be effective in the prevention of preterm preeclampsia and other perinatal adverse outcomes.

NCT ID: NCT05528536 Recruiting - Chronic Pain Clinical Trials

Acceptance and Commitment Therapy and Exercise for Older Adults With Chronic Pain

Start date: May 15, 2022
Phase: N/A
Study type: Interventional

The objective is to investigate on the effectiveness of Acceptance and Commitment Therapy and Exercise in: (Primary outcomes) 1. Increasing psychological flexibility 2. Reducing pain interference 3. Increasing quality of life 4. Increasing physical functioning (Secondary outcomes) 5. Reducing psychological distress - depression & anxiety

NCT ID: NCT05438238 Recruiting - Infertility Clinical Trials

Virtual Reality for Acute Pain and Anxiety During Egg Retrieval for in Vitro Fertility Treatment

Start date: February 1, 2023
Phase: N/A
Study type: Interventional

This study is a comparison between the current standard practice of performing a transvaginal oocyte retrieval (TVOR) with paracervical block (PCB) and a relatively recently developed technology of virtual reality that is added to the above mentioned standard practice of TVOR + PCB. The aim of the study is to find out whether this newer technology has an advantage for the patient, in terms of anxiety and pain reduction or satisfaction.

NCT ID: NCT05378607 Recruiting - HIV Clinical Trials

Goals for Adherence With Low-cost Incentives

GOALS
Start date: April 18, 2022
Phase: N/A
Study type: Interventional

GOALS is a three-year randomized control trial (RCT) aimed at testing the effectiveness of three incentive designs to improve the ART adherence of those in need of adherence support. Participants in the first treatment group (T1, n=140) will be eligible for a prize drawing every three months if they reach the adherence target set for them by the study team, gradually increasing from their baseline adherence towards 90% by the end of the year. Participants in the second treatment group (T2, n=140) will be eligible if they reach the adherence target they set for themselves (subject to reaching 90% at the end of year 1 and each target being at least as high as the previous one). Participants in the third treatment group will have a fixed adherence target of 90% and will be eligible for a prize drawing every three months if this target is reached. All treatment groups will receive weekly motivational messages and a reminder of the upcoming prize drawing. The control group (T4, n=140) will receive the usual standard of care offered by the hospital and weekly motivational messages. Primary outcomes measured using Wisepill devices are mean ART adherence and the fraction of clients with adherence of 90% or more. Secondary outcomes are viral suppression, the fraction of clients with treatment interruptions of 48hrs or more, and retention in care.

NCT ID: NCT05358678 Recruiting - Cesarean Section Clinical Trials

Cesarean Section Scar Niche: The Impact on ART Outcome

Start date: May 25, 2022
Phase:
Study type: Observational

To evaluate the impact of the presence of cesarean section niche and its characteristics on the outcome of ART cycles.

NCT ID: NCT05090150 Recruiting - HIV Clinical Trials

The SMART ART Study

Start date: November 2, 2021
Phase: N/A
Study type: Interventional

The investigators propose A Sequential Multiple Assignment Randomized Trial of scalable interventions for ART delivery in South Africa- the SMART ART study-a randomized study to test adaptive ART delivery for persons with detectable viral load and/or not engaged in care.The types of differentiated service delivery (DSD) that will be examined in this study are incentives, community-based ART, and home delivery. The study plans to enroll up to 900 participants-people living with HIV and who are eligible for ART and living in KwaZulu-Natal, South Africa. The study aims to maximize the proportion of ART eligible persons living with HIV who achieve viral suppression at 18 months. The study will also evaluate the preferences of clients and providers for differentiated service delivery, and evaluate the cost effectiveness of adaptive HIV treatment for those who are not engaged in care.

NCT ID: NCT05075174 Recruiting - ART Clinical Trials

Effect of Progesterone Levels on 15th Day After Embryo Transfer in Early Miscarriage < 7 WG or Evolving Pregancy Rates

Start date: November 1, 2020
Phase:
Study type: Observational

Progesterone level has been studied at days before embryo transfert. But, progesterone blood level has not been studied 15 days after embryo transfert. The aim of this study is to study progesterone level impact at 15 days after embryo transfert on evolving pregnanies or early miscarriages.