Increasing Treatment Efficacy Using SMART Methods for Personalizing Care

Status Active, not recruiting

Clinical Trial Summary

The proposed study will determine the feasibility, tolerability, and acceptability of a study that tests: 1) personalized treatment delivery (i.e., module sequencing and treatment discontinuation timing) aimed at increasing the efficiency of care, and 2) the research protocol designed to evaluate the effects of this personalized care. A sample of 60 participants with heterogeneous anxiety disorders (and comorbid conditions, including depression) will be enrolled in a pilot sequential multiple assignment randomized trial (SMART). Patients will be randomly assigned to one of three sequencing conditions: transdiagnostic treatment administered in its standard module order, module sequences that prioritize capitalizing on relative strengths, and module sequences that prioritize compensating for relative weaknesses. Next, after 6 sessions, participants will be randomly assigned to either continue or discontinue treatment to evaluate post-treatment change at varying levels of target engagement. This proposal will enable us to 1) test the feasibility, acceptability, and tolerability of the research protocol, treatment sequencing conditions, and early treatment discontinuation, 2) determine whether a preliminary signal that capitalization or compensation module sequencing improves treatment efficiency exists, and 3) explore preliminary associations between core process engagement at treatment discontinuation and later symptom improvement. The proposed study, and the subsequent research it will support, will inform evidence-based decision rules to make existing treatments more efficient, ultimately reducing patient costs and increasing the mental health service system's capacity to address the needs of more individuals.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04642898
Study type	Interventional
Source	University of Kentucky
Contact
Status	Active, not recruiting
Phase	N/A
Start date	June 22, 2021
Completion date	June 30, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03535805` - Transdiagnostic, Cognitive and Behavioral Intervention for in School-aged Children With Emotional and Behavioral Disturbances	N/A
Active, not recruiting	`NCT05006976` - A Naturalistic Trial of Nudging Clinicians in the Norwegian Sickness Absence Clinic. The NSAC Nudge Study	N/A
Recruiting	`NCT05419934` - EMDR Therapy in Young Children, a Double-blinded Randomized Controlled Trial	N/A
Active, not recruiting	`NCT04136054` - Better Sleep in Psychiatric Care - Anxiety and Affective Disorders	N/A
Completed	`NCT04091139` - Research of Unified Protocol for the Treatment of Common Mental Disorders in Adolescents in Hong Kong	Phase 2/Phase 3
Completed	`NCT04647318` - Physiological Response to Self-compassion Versus Relaxation	N/A
Active, not recruiting	`NCT05114824` - Acceptability and Feasibility of an 8-week Online Mindfulness-Based Cognitive Therapy Program Among Undergraduate Students	N/A
Recruiting	`NCT05843695` - Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety	N/A
Completed	`NCT05078450` - Mood Lifters Online for Graduate Students and Young Professionals	N/A
Not yet recruiting	`NCT06162624` - Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons	N/A
Not yet recruiting	`NCT05747131` - Emotion Detectives In-Out: Feasibility and Efficacy of a Blended Version of the Unified Protocol for Children	N/A
Not yet recruiting	`NCT05863637` - Intensive Short-Term Dynamic Psychotherapy (ISTDP) for Anxiety Diagnoses in a Primary Care Setting	N/A
Not yet recruiting	`NCT05225701` - Efficacy of a Transdiagnostic Guided Internet-Delivered Intervention for Emotional, Trauma and Stress-Related Disorders.	N/A
Completed	`NCT02579915` - Developing a Low-Intensity Primary Care Intervention for Anxiety Disorders (AIM-PC)	N/A
Recruiting	`NCT02376959` - Effect of Spiritist "Passe" Energy Therapy in Reducing Anxiety in Volunteers	N/A
Recruiting	`NCT02186366` - Efficacy Study of Abdominal Massage Therapy to Treat Generalized Anxiety Disorder of Deficiency of Both Heart and Spleen Type	N/A
Not yet recruiting	`NCT02126787` - Short-term, Intensive Psychodynamic Group Therapy Versus Cognitive-behavioral Group Therapy in the Day Treatment	N/A
Withdrawn	`NCT01953042` - Benefits of a Psychoeducation Program for Those Awaiting Treatment for OCD and OCD Spectrum Disorders	N/A
Completed	`NCT02134730` - School-based Universal Prevention for Anxiety and Depression in Sweden: A Cluster-randomized Trial	N/A
Completed	`NCT01636791` - CBT Versus a Return to Work Intervention for Patients With Common Mental Illness in Primary Care	Phase 3