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Transplantation of Bone Marrow Mesenchymal Stromal Cells for Periodontal Regeneration — BMMSC  

Aggressive Periodontitis Clinical Trial

Official title:
Transplantation of Bone Marrow Mesenchymal Stromal Cells for Bone Regeneration in Periodontal Disease

Clinical Trial Summary

The goal of this study is to evaluate the capacity of allogeneic bone marrow mesenchymal stromal cells (MSC) to induce bone regeneration in patients with periodontal disease. MSC cultured are loaded on a collagen scaffold, included into autologous platelet rich plasma clot and implanted in the bone defect.

Clinical Trial Description

The clinical protocol is designed to evaluate the bone regeneration capacity of allogeneic MSCs for the treatment of patients with chronic or aggressive periodontal disease. Patients with either a 2- or 3-wall intrabony defects are included in this study. A bioengineering construct, constituted by allogeneic MSCs and a collagen scaffold, is incorporated into platelet rich plasma (PRP) clot, which is implanted at the bone defect site. Follow up of treated tooth are assessed by clinical evaluation, intraoral radiography and cone-beam CT. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05975892
Study type Interventional
Source Instituto Venezolano de Investigaciones Cientificas
Contact
Status Enrolling by invitation
Phase Phase 1/Phase 2
Start date August 30, 2018
Completion date August 30, 2024
View Details
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