Clinical Trials Logo

Clinical Trial Summary

Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria. Leukocyte and platelet-rich fibrin (L-PRF) has been used extensively in the treatment of intrabony defects and achieved excellent results. It acts as an immune regulation node with inflammation control abilities, including a slow continuous release of growth factors which stimulates periodontal regeneration. The aim of this study is to evaluate the adjunctive effects of aPDT with and without L-PRF in aggressive periodontitis patients.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05043935
Study type Interventional
Source Kafrelsheikh University
Contact Dalia R Issa, PhD
Phone 01007753636
Email dalia_rasheed@hotmail.com
Status Recruiting
Phase N/A
Start date November 22, 2021
Completion date October 2024

See also
  Status Clinical Trial Phase
Terminated NCT01993368 - Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis N/A
Completed NCT02282800 - Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients N/A
Recruiting NCT02833285 - B Cell Functions in Periodontitis
Completed NCT02127203 - Nitro-oxidative Stress in Periodontitis N/A
Completed NCT02223702 - Alternative Antibiotic Regime in the Treatment of GAgP Phase 4
Completed NCT03093246 - Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Phase 2/Phase 3
Completed NCT03093207 - Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Phase 2/Phase 3
Completed NCT05295576 - Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients
Completed NCT05297084 - Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive Periodontitis
Completed NCT02969928 - Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis Phase 2/Phase 3
Completed NCT02829983 - Clarithromycin as Adjuvant to Periodontal Debridement N/A
Completed NCT02927704 - Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 N/A
Completed NCT02817568 - Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP N/A
Active, not recruiting NCT04051255 - Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Periodontitis. N/A
Completed NCT05001919 - Concentrated Growth Factors in Treatment of Intrabony Defects in Localized Aggressive Periodontitis Phase 1/Phase 2
Completed NCT03727620 - Doxycycline in the Treatment of Aggressive Periodontitis Phase 1/Phase 2
Completed NCT04223869 - IL-34 Levels in Various Types of Periodontitis N/A
Completed NCT03034824 - Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels N/A
Completed NCT02049008 - Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Phase 4
Recruiting NCT01510808 - The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis N/A