Clinical Trials Logo
  1. Home
  2. Aggressive Periodontitis
  3. NCT05297084

Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive Periodontitis

Aggressive Periodontitis Clinical Trial

Official title:
Effect of Non Surgical Periodontal Treatment on Clinical Parameters and Gingival Crevicular Fluid Il-17 and Il-18 Levels in Aggressive Periodontitis Patients

Clinical Trial Summary

clinical parameters and IL-17 and Il-18 GCF levels were measured in 25 aggressive periodontitis patients compared to 25 periodontally healthy individuals. It was observed that that Clinical parameters and Il-17 and Il-18 levels are higher before treatment but decreased after treatment which suggests role of these interleukins in pathogenesis of aggressive periodontitis .

Clinical Trial Description

Aggressive periodontitis is a type of rapidly progressing periodontal diseases .The three classic primary characteristics of this disease are ; occurring in young healthy patients with rapid attachment loss and familial aggregation .Bacteria-host interactions, insufficiencies in host defenses and possibly a genetic predisposition represent the etiologic factors . Beside the young age of onset, important factors as involvement of host factors and non-plaque-related etiologic factors have also been proposed . Aim of the study: Objectives were to compare and correlate the clinical parameters and biochemical parameters (Il-17 and Il-18 levels in GCF) of aggressive periodontitis patients (At baseline and after three months of nonsurgical treatment) versus periodontally healthy subjects at baseline. Subjects and methods: Populations included in the study: A total of fifty individuals were enrolled and categorized as; group A that included twenty five aggressive periodontitis patients and group B which included twenty five periodontally healthy controls. Clinical parameters: Plaque index (PI) ,gingival index (GI), Probing pocket depth (PPD) and clinical attachment level (CAL) were measured at baseline for both groups and after three months of non surgical periodontal treatment completion for group A. GCF sampling: In group A ,the site with deepest probing depth was selected for GCF sampling while for group B , any site was sampled using PerioPaper strips . Phase I periodontal treatment After baseline GCF sample collection and clinical measurement recordings, group A patients received phase I periodontal treatment. Analysis of Il-17 and Il-18 levels in GCF: GCF samples were examined by enzyme-linked immunosorbent assay (ELISA).Procedures were performed according to the directions in the kits. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05297084
Study type Observational
Source Future University in Egypt
Contact
Status Completed
Phase
Start date March 27, 2021
Completion date December 30, 2021
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05043935 - The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis N/A
Terminated NCT01993368 - Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis N/A
Completed NCT02282800 - Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients N/A
Recruiting NCT02833285 - B Cell Functions in Periodontitis
Completed NCT02127203 - Nitro-oxidative Stress in Periodontitis N/A
Completed NCT02223702 - Alternative Antibiotic Regime in the Treatment of GAgP Phase 4
Completed NCT03093207 - Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Phase 2/Phase 3
Completed NCT03093246 - Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Phase 2/Phase 3
Completed NCT05295576 - Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients
Completed NCT02969928 - Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis Phase 2/Phase 3
Completed NCT02829983 - Clarithromycin as Adjuvant to Periodontal Debridement N/A
Completed NCT02927704 - Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 N/A
Completed NCT02817568 - Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP N/A
Active, not recruiting NCT04051255 - Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Periodontitis. N/A
Completed NCT05001919 - Concentrated Growth Factors in Treatment of Intrabony Defects in Localized Aggressive Periodontitis Phase 1/Phase 2
Completed NCT03727620 - Doxycycline in the Treatment of Aggressive Periodontitis Phase 1/Phase 2
Completed NCT04223869 - IL-34 Levels in Various Types of Periodontitis N/A
Completed NCT03034824 - Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels N/A
Completed NCT02049008 - Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Phase 4
Recruiting NCT01510808 - The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis N/A