Acute Stroke Clinical Trial
Official title:
3T Stroke MRT for Examining Mismatch in the CSB of the Charité Universitätsmedizin Berlin (3Tesla in 1000+)
The purpose of this study is to compare clinical and economic parameters of stroke patients who have received acute MRI imaging (test group) to patients who have received routine CT imaging (control group) in the clinical setting of acute stroke.
The primary objective:
- Prospective validation of infarct development in ischemic stroke and transitory
ischemic attacks on the basis of all patients given a preliminary diagnosis of stroke
or TIA in the emergency ward of the Benjamin Franklin Campus of
Charité-Universitätsmedizin Berlin.
Secondary objectives:
- Determination of the spontaneous reperfusion rate in patients with an initial mismatch
in the correlation between the time from onset of symptoms to the time of first imaging
and NIHSS score severity
- Characterization of metabolic changes in ischemic tissue in cases of minor subcortical
infarct using high resolution diffusion weighted MRI (DWI) and perfusion MRI with 2nd
pass corrected CBF cards
- Proof of the principle that stroke MRI can improve patient care / shorten the period in
which patients are bedridden
- Measurement of the diffusion tensor in acute ischemic stroke (Hamburg DTI study)
- Proof of structural damage and investigation of pathogenesis in patients suffering from
clinical transitory ischemic attacks (TIA)
- Investigation of the correlation of clinical symptoms and lesion site as well as of
changes in cortical plasticity in patients with solitary thalamus infarct
- Brain plasticity and motor learning in cases of a purely cortical infarct
- Characterization of gender specific damage patterns in stroke
- Morphologic and pathophysiological typing of the cryptic and cardial embolic infarct in
correlation to incidence of arrhythmia
- Characterization of localization and morphology of infarcts in patients presenting in
the emergency ward with central vestibular nerve syndrome / recording frequency of
cerebral sessions in patients presenting with a primary diagnosis of central vestibular
nerve lesion
- Clinical characterization of cerebellar and brain stem infarcts which are accompanied
by vertigo symptoms and their correlation to infarct location
;
Observational Model: Cohort, Time Perspective: Prospective
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