Acute Stroke Clinical Trial
— BEHABISOfficial title:
The Bern Heart and Brain Interaction Study - Interaction Between Brain and Heart in Acute Ischemic Stroke
Acute ischemic stroke is caused by blockage of blood vessels in the brain. Blood vessels can be obstructed by several different mechanisms and identification of this cause is essential to minimize the risk of recurrence.
Status | Recruiting |
Enrollment | 220 |
Est. completion date | December 31, 2023 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 86 Years |
Eligibility | Inclusion Criteria: - Informed consent as documented by signature. - Age: = 18 and < 86 years. - Acute ischemic stroke with symptom onset within 12 hours before admission to hospital. - Diagnosis of acute ischemic stroke with MRI with diffusion restriction as seen on diffusion weighted imaging. Exclusion Criteria: - Pregnancy. A negative pregnancy test upon admission is required for all women with child-bearing potential. - Standard contraindication for performing MRI. - Severe renal failure (GFR <40). |
Country | Name | City | State |
---|---|---|---|
Switzerland | Bern University Hospital - Inselspital | Bern | BE |
Lead Sponsor | Collaborator |
---|---|
University Hospital Inselspital, Berne |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Prevalence of neurogenic stunned myocardium (NSM) in ischemic stroke patients with elevated hsTnT (= 0.015 mg/L) | 48 hours | ||
Primary | Prevalence of neurogenic stunned myocardium (NSM) in ischemic stroke patients with elevated hsTnT (= 0.015 mg/L) | 3 months | ||
Secondary | Prevalence of sub(acute) and chronic myocardial infarction in stroke patients with and without elevated hsTnT (= 0.015 mg/L) | At baseline, 24 hours, 48 hours, 3 months | ||
Secondary | Positive and negative predictive value of the developed predictive score to detect myocardial infarction and neurogenic stunned myocardium compared to CMR and coronary angiography | At baseline, 24 hours, 48 hours, 72 hours, 3 months | ||
Secondary | Influence of neurogenic stunned myocardium on neurological outcome (as measured by modified Rankin Scale) | The modified Rankin Scale (mRS) measures the degree of disability or dependence (minimum: 0 [normal]; maximum: 6 [death]). Favorable outcome is defined as a mRS score of 0 to 4, poor outcome as a mRS score of 5 or 6. | At baseline, 24 hours, 3 months | |
Secondary | Influence of neurogenic stunned myocardium on brain infarct size (as measured by brain MRI) | At baseline, 24 hours, 3 months |
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