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Application of Index of Microcirculatory Resistance to Evaluate Myocardial Protection After Ischemic Adaptation

Acute Myocardial Infarction Clinical Trial

Official title:
Application of Index of Microcirculatory Resistance to Evaluate Myocardial Protection After Ischemic Adaptation

Clinical Trial Summary

To evaluate the protective effect of IPC on the myocardial microcirculation response through IMR and the predictive value of IMR on the degree of myocardial reperfusion and the prognosis of patients.

Clinical Trial Description

This study is a clinical randomized controlled study, applying index of microcirculatory resistance (IMR) to evaluate the myocardial protection of ischemic postconditioning (IPC) in patients receiving direct PCI treatment for acute myocardial infarction.IMR is a quantitative evaluation index of microcirculation status. IPC has been reported to reduce ischemia-reperfusion injury and has a myocardial protective effect.The research plan divides patients into IPC and non-IPC groups at random. After the infarction-related artery is successfully implanted with a stent, the pressure guide wire is used to measure IMR and CFR in the state of maximal expansion of the microcirculation induced by intravenous ATP infusion.And analyze whether there are differences in indicators between the two groups and the relationship between these indicators and the patient's myocardial level reperfusion, cardiac function and prognosis.The purpose is to evaluate the myocardial protection of IPC and the predictive value of IMR on the degree of myocardial reperfusion and the prognosis of patients. It is expected that the target IPC can improve the IMR value, and IMR can predict the degree of myocardial reperfusion and cardiac function and prognosis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04952740
Study type Interventional
Source Peking University Third Hospital
Contact
Status Completed
Phase N/A
Start date January 1, 2014
Completion date June 30, 2015
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