Belinostat and Bortezomib in Treating Patients With Relapsed or Refractory Acute Leukemia or Myelodysplastic Syndrome

Acute Myeloid Leukemia Clinical Trial

Official title:

Phase I Study of Belinostat (PXD-101) and Velcade (Bortezomib) in Relapsed or Refractory Acute Leukemia/ Myelodysplastic Syndrome

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01075425
• Other study ID #: MCC-12517
• Secondary ID: NCI-2010-00127RC
• Status: Completed
• Phase: Phase 1
• First received: February 15, 2010
• Last updated: April 13, 2016
• Start date: May 2010
• Est. completion date: February 2015

Study information

• Verified date: April 2016
• Source: Virginia Commonwealth University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

RATIONALE: Belinostat and bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving belinostat together with bortezomib may kill more cancer cells. PURPOSE: This phase I trial is studying the side effects and best dose of giving belinostat together with bortezomib in treating patients with relapsed or refractory acute leukemia or myelodysplastic syndrome.

Description:

PRIMARY OBJECTIVES: I. To determine the recommended phase II doses for the combination of bortezomib and belinostat in patients with relapsed or refractory acute leukemia (AL), myelodysplasia (MDS), and chronic myelogenous leukemia in blast crisis. SECONDARY OBJECTIVES: I. Determine safety and tolerance and describe the toxicities of the combination. II. To demonstrate adequate methods for the assessment of pharmacodynamic response of leukemia cells from the bone marrow and/or peripheral blood in terms of effects on NF-kB (nuclear RelA by immunofluorescence microscopy), NF-kB dependent proteins XIAP and Bcl-xL, and BIM, and document pharmacodynamic responses observed in the course of this study. III. To document activity of the combination observed in the course of this study. OUTLINE: Patients receive belinostat IV over 30 minutes on days 1-5 and 8-12 and bortezomib IV on days 1, 4, 8, and 11. Treatment repeats every 21 days for up to 12 courses in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed periodically.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 41
• Est. completion date: February 2015
• Est. primary completion date: February 2015
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion

• Relapsed or refractory acute leukemia

• acute myeloid leukemia (AML) other than APL

• acute lymphocytic leukemia (ALL)

• acute leukemia that has evolved from a prior myelodysplastic syndrome - no requirement for prior therapy

• myelodysplastic Syndrome (MDS) - International Prognostic Scoring System (IPSS) intermediate-2 or greater

• chronic myelogenous leukemia with myeloid or lymphoid blast crisis

• WBC =< 50 x 10^9/L; hydroxyurea or leukopheresis may be used prior starting treatment

• Prior allogeneic stem cell transplant is allowed provided that >/= 12 months have elapsed since allogeneic transplant; no graft versus host disease is present; not currently on immunosuppressive therapy

• AST, ALT =< 2.5 x upper limit of normal (ULN)

• Female subject who is post-menopausal or surgically sterilized or willing to use an acceptable method of birth control (i.e., oral or injectable hormonal methods; barrier methods such as intra-uterine device, diaphragm with spermicide, condom with spermicide, or abstinence) for the duration of the study

• Male subject agrees to use an acceptable method for contraception for the duration of the study

• Serum total bilirubin =< 1.5 x upper limit of normal

• Serum potassium >= 3.5 mEq/L and serum magnesium >= 1.7 mEq/dL (electrolytes may be corrected with supplementation)

• ECOG Performance Status (PS) =<2

• Creatinine =< 1.5 x upper limit of normal or calculated or actual creatinine clearance > 45 mL/min

Exclusion

• Willing and medically suitable for remission induction with other agents in anticipation of a potentially curative allogeneic bone marrow transplant

• Known CNS malignant disease

• Prior severe allergic reactions to bortezomib, mannitol, boron, belinostat or compounds of the hydroxamate class or arginine

• Grade 1 with pain or Grade >= 2 peripheral neuropathy or paresthesias within 14 days before enrollment

• History of sustained ventricular tachycardia, ventricular fibrillation, Torsade de Pointes, or resuscitated cardiac arrest

• History of resuscitated cardiac arrest. Note: persons without pre-existing cardiovascular comorbidities who have experienced resuscitated cardiac arrest in the setting of sepsis ARE eligible provided they have no residual cardiac abnormalities and providing they do not require ongoing medication to manage cardiac issues as an outcome of such an event.

• Conduction abnormality or concomitant treatment with an anti-arrhythmic agent to prevent or control arrhythmia

• Known congenital long QT syndrome

• Clinically significant infection including infection with HIV, or active hepatitis B or C

• Significant cardiovascular disease, hypertrophic cardiomegaly or restrictive cardiomyopathy, myocardial infarction within the past 6 months, unstable angina

• Baseline QTc interval > 450 msec

• Planned or ongoing treatment with any drug that may be risk of causing Torsades de Pointes

• Persistent blood pressure (BP) of >=160/95

• Serious medical or psychiatric illness likely to interfere with patient participation

• Pregnant or nursing

• Diagnosis or treatment for another malignancy within 3 years of enrollment, with the exception of complete resection of basal cell carcinoma or squamous cell carcinoma of the skin, an in situ malignancy, or low risk prostate cancer after curative therapy

• Planned ongoing treatment with other drugs thought to potentially adversely interact with belinostat

• Strong or moderate CYP3A4 inhibitors

• Patient has received other investigational drugs within 14 days before enrollment

• If steroids for cancer control have been used, patients must be off these agents for >/= 1 week before starting treatment. Exception: maintenance therapy for non-malignant disease with prednisone or steroid equivalent dose < 10 mg/day is permitted.

Study Design

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Acute Lymphocytic Leukemia
• Acute Myeloid Leukemia
• Chronic Myelogenous Leukemia
• Leukemia
• Leukemia, Lymphoid
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive
• Leukemia, Myeloid
• Leukemia, Myeloid, Acute
• Myelodysplastic Syndrome
• Myelodysplastic Syndromes
• Precursor Cell Lymphoblastic Leukemia-Lymphoma
• Preleukemia
• Syndrome

Intervention

Drug:
• bortezomib
Given IV
• belinostat
Given IV

Other:
• laboratory biomarker analysis
Correlative studies

Genetic:
• western blotting
Correlative studies

Other:
• pharmacological study
Correlative studies
• flow cytometry
Correlative studies

Locations

Country	Name	City	State
United States	M D Anderson Cancer Center	Houston	Texas
United States	Virginia Commonwealth University	Richmond	Virginia

Sponsors (2)

Lead Sponsor	Collaborator
Virginia Commonwealth University	National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Recommended phase II doses for the combination of bortezomib and belinostat		2 years	Yes
Secondary	Toxicity		2 years	Yes
Secondary	Pharmacodynamic response		2 years	No
Secondary	Activity of belinostat and bortezomib		3 years	No

External Links

•   VCU Massey Cancer Center