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Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-Ⅲ）

Acute Ischemic Stroke Clinical Trial

Official title:
Thrombolysis Treated by TNK-tPA in Acute Ischemic Stroke Patients: a Multi-center, Block Randomized, Positive Drug Parallel Control and Non-inferior Phase Ⅲ Trial, 3T Stroke-Ⅲ

Clinical Trial Summary

The trial is prospective, randomized, open-label, blinded endpoint (PROBE) design. Patients with acute ischemic stroke, who are eligible for standard intravenous thrombolysis within 4.5 hours of stroke onset will be randomized 1:1 to 0.25mg/kg or 0.9 mg/kg alteplase before all participants undergo endovascular thrombectomy.

Clinical Trial Description

The study will be a multi-center, prospective, randomized, open- label, blinded endpoint (PROBE), controlled phase 3 trial (2 arm with 1:1 randomization) in ischemic stroke patients. Imagine is performed with CT or MRI acutely with imaging follow-up at 24-36 hours. The sample size is 1630. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05745259
Study type Interventional
Source Beijing Tiantan Hospital
Contact Yongjun Wang
Phone 13911172565
Email yongjunwang111@aliyun.com
Status Recruiting
Phase Phase 3
Start date October 26, 2022
Completion date March 29, 2024
View Details
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