Acute Ischemic Stroke Clinical Trial
Official title:
Remote Ischemic Conditioning for the Treatment of Stroke-related Insomniaļ¼A Multicenter, Randomized, Double-blind, Sham-controlled Trial.
This study intends to further reveal the effect of RIC in stroke-related insomnia and explore its potential mechanisms.
Sleep disturbance after stroke is an important factor affecting the prognosis of stroke function. At present, most studies have focused on the diagnosis and treatment of sleep disordered breathing after stroke, while stroke-related insomnia has been neglected. Therefore, it is of great significance to explore a treatment that combines stroke protection with sleep improvement. Remote ischemic conditioning (RIC) triggers endogenous protective effect through transient and repeated ischemia in the limb to protect remote tissues and organs. The mechanisms of LRIC involve the regulation of autonomic nervous system, release of humoral factors, improvement of vascular endothelial function and modulation of immune/inflammatory responses, which participate in the regulation of sleep after stroke.Therefore, this study intends to conduct a randomized controlled trial to further reveal the effect of RIC in stroke-related insomnia and explore its potential mechanisms. ;
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