Acute Ischemic Stroke Clinical Trial
Official title:
To Evaluate the Role of Plasma Catecholamine Levels in Predicting the Development of Myocardial Depression in Acute Neurological Patients
NCT number | NCT03801694 |
Other study ID # | 2018H0436 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | December 3, 2018 |
Est. completion date | April 14, 2024 |
Verified date | April 2024 |
Source | Ohio State University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The purpose of this study is to assess the levels of serum catecholamines associated with myocardial depression (MD) in patients with acute neurological injury.
Status | Completed |
Enrollment | 4 |
Est. completion date | April 14, 2024 |
Est. primary completion date | April 14, 2024 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 50 Years and older |
Eligibility | Inclusion Criteria: - female patients >50 years admitted to the neuro ICU with diagnosis of either acute ischemic stroke or subarachnoid hemorrhage - Only patients predicted to be on norepinephrine infusion for at least 48 hrs will be selected. Exclusion Criteria: - patients with known history of heart failure will be excluded - Patients with history of coronary artery disease, smoking, poorly controlled diabetes with HbA1c >8 and uncontrolled hypertension will be excluded. - Patients with poor ECHO windows will be excluded |
Country | Name | City | State |
---|---|---|---|
United States | The Ohio Sate University | Columbus | Ohio |
Lead Sponsor | Collaborator |
---|---|
Ohio State University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Association of plasma catecholamine levels with stress induced cardiomyopathy | Baseline plasma catecholamine levels as well as daily levels will be measured until up to 5 days from study onset. Baseline transthoracic ECHO followed by daily ECHO with strain imaging will be obtained to assess for evidence of myocardial depression. The investigators will assess the correlation of plasma catecholamine levels (i.e level of dopamine, epinephrine and norepinephrine) in the development of myocardial depression. In other words, the investigators will evaluate the level of catecholamines that is associated with stress induced cardiomyopathy. If participants develop symptomatic heart failure before 5 days, study will stop at that point. | up to 5 days | |
Primary | Association of troponin levels with stress induced cardiomyopathy | Baseline troponin level will be measured as well as daily levels will be obtained for 5 days. The investigators will study the correlation of troponin levels with the myocardial depression noted on ECHO. | up to 5 days | |
Secondary | Association of ST-T changes on EKG with stress induced cardiomyopathy | Baseline EKG and daily EKG measurements will be taken. These will be examined for ST-T wave changes in participants with evidence of myocardial depression on ECHO. | up to 5 days |
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