Wound Heal Clinical Trial
Official title:
Early Healing of Oral Soft Tissues: a Clinical and Biomolecular Analysis Part I - Gene Expression and Cellular Behaviour 24-hours After Injury
The purpose of the present study is to observe and compare -through a biomolecular analysis-
the differences in the gene expression and cellular behavior in the early wound healing
process -24 hours after injury- between the following three oral tissues: alveolar mucosa,
buccal gingiva and palatal tissue.
The main hypothesis is that there is a difference in the gene expression and in the cellular
behaviour between the three oral tissues studied and this difference can be observed at 24
hours post-injury.
The wound healing is an extremely complex process. It has been observed that oral wounds
mechanisms present special features. In fact, mucosal wounds demonstrated accelerated healing
compared to cutaneous wounds.
Numerous comparative studies have described important differences of cellular behavior and
genes expression between oral mucosal and dermal tissues. Moreover, it has been observed that
the behavior of the cells is autonomous, i.e., that greatest differences seen in the genomic
response after injury in skin and mucosa are derived, in part, from intrinsic differences in
the genetic regulation of the cells at each site. Also, it is important to highlight the fact
that it has been observed that the cellular response after wound is early, showing the first
and greatest changes at 12-24 hours post injury. Moreover, a recent study has been raised the
possibility of that the transcriptional regulatory networks responsible for the accelerated
healing in oral mucosa are already present in the unwounded state.
In the oral mucosal tissues, the mechanisms underlying scar-less wound healing have been
studied. Most studies have focused on the cellular characteristics and the molecular
expression as growing factors, inflammatory mediators, etc., and have evaluated the process
in later periods.
Therefore, while the biomolecular basis of the differences in oral mucosal and dermal tissues
wound healing have been described, this is less well understood in the different oral soft
tissue wounds.
The following points must be considered:
- The differences in the wound healing between mucosal and dermal tissues have been
extensively studied through biomolecular analysis.
- The behavior of the cells is autonomous.
- The changes in the wound healing have been observed after 12-24 hours post-injury.
- The transcriptional regulatory networks responsible for the accelerated healing in oral
mucosa could already be present in the unwounded state.
- The differences in the wound healing between the different oral soft tissues (alveolar
mucosa, buccal gingiva and palatal tissue) has not been studied from a biomolecular
point of view; however, differences in the clinical behavior and response between these
three oral tissues has been reported.
The main questions are:
1. Twenty-four hours after injury: Are there differences in the gene expression and
cellular behaviour between the three studied tissues?
2. The transcriptional regulatory networks responsible for the accelerated oral tissues
healing:
- Are presents in the unwounded state?
- Are differences between the three studied oral tissues?
Deepen the knowledge in the early wound healing process of these tissues and the difference
between them -evaluating the genes expression and the behavior of the cells- could allow the
generation of new approaches to improve the healing of oral wounds.
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