Weight Loss Clinical Trial
Official title:
CLINICAL EVALUATION OF GCB-70 IN OVERWEIGHT SUBJECTS:An Add-On Study
Clinical evaluation of GCB-70 in overweight subjects: An Add-On Study
In recent years the prevalence of obesity has increased reaching epidemic levels. Obesity
can be defined as excess accumulation of body fat arising from a sustained or a periodic
positive energy balance that is when energy intake exceeds energy expenditure. Overweight
and obesity is based on Body Mass Index (BMI) Accordingly to the World Health Organization
(WHO) classifies individuals with BMI 25-29.99 kg/m2 as overweight while individuals with
BMI≥ 30 kg/m2 are termed obese. Apart from being a major contributor to chronic disease
burden and mortality, obesity-particularly abdominal obesity, is also closely related to the
metabolic syndrome, a cluster of diseases that encompasses the following conditions
Dyslipidemia, Hypertension Glucose intolerance and insulin resistance.Abdominal obesity The
World Health Organization predicts there will be 2.3 billion overweight adults in the world
by 2015, and more than 700 million of them will be obese. Worldwide obesity has more than
doubled since 1980. In 2008, 1.5 billion adults, 20 years of age and older, were overweight.
Of these, over 200 million men and nearly 300 million women were obese. Over 65% of the
world population lives in countries where overweight and obesity kills more people than
underweight .
Overweight and obesity have become a serious health concern . Different weight management
strategies are presently utilized and a variety of weight loss supplements sold as "slimming
aids" are readily available. However, the efficacy of some of these food supplements remains
uncertain. With the high cost of prescription weight loss drugs and the fear of side
effects, the general public is turning to nutraceuticals. One such supplement is the green
coffee extract (GCE).GCE is present in green or raw coffee.
Coffee (Coffea L.) is the world's favourite beverage and the second-most traded commodity
after oil. In 2009/10 coffee accounted for exports worth an estimated US$ 15.4 billion, when
some 93.4 million bags were shipped, with total coffee sector employment estimated at about
26 million people in 52 producing countries. Arabica coffee (Coffea arabica L.) and robusta
coffee (C. canephora Pierre ex A.Froehner) are the two main species used in the production
of coffee. 66% of the world production mostly comes from Coffea arabica L. and 34% from
Coffea canephora. Coffee belongs to family Rubiaceae in the genus Coffea.
GCB-70 is obtained from raw seeds or beans of Coffee. In producing the normal coffee for
sale, the berries are roasted to produce the traditional beverage. However, no roasting is
done for green extract so as to preserve important components
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